An overview of the current state of phage therapy for the treatment of biofilm-related infections

IF 5.7 2区 医学 Q1 VIROLOGY
Diana P Pires , Luciana Meneses , Ana C Brandão , Joana Azeredo
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引用次数: 12

Abstract

Bacterial biofilms are involved in many chronic and difficult-to-treat infections. Phage therapy against infectious biofilms is becoming a promising strategy, as suggested by the increasing number of publications demonstrating the efficacy of phages against in vitro formed biofilms. However, the translation between in vitro results to in vivo phage therapy outcome is not straightforward due to the complexity of phage-biofilm interactions in clinical contexts. Here, we provide a critical overview of the in vitro studies of phages for biofilm control of clinical pathogens, followed by the major outcomes and lessons learned from the recently reported case studies (between 2018 and 2021) of phage therapy against biofilm-related infections.

噬菌体治疗生物膜相关感染的现状综述
细菌生物膜与许多慢性和难以治疗的感染有关。噬菌体治疗感染生物膜正在成为一种有前途的策略,越来越多的出版物表明,噬菌体对体外形成的生物膜有功效。然而,由于临床环境中噬菌体-生物膜相互作用的复杂性,体外结果与体内噬菌体治疗结果之间的转化并不简单。在这里,我们提供了噬菌体用于临床病原体生物膜控制的体外研究的重要概述,然后是最近报道的噬菌体治疗生物膜相关感染的病例研究(2018年至2021年)的主要结果和经验教训。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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