Bio Actives from Albizia Lebbeck on Acute Lung Injury/ Acute Respiratory Distress Syndrome Molecular Targets: In-Silico Study

Abstract

This contemporary work is prepared with the aim of presenting natural phytoconstituents obtained from Albizia lebbeck (Bronco T) as a remedial option against Acute Lung Injury / Acute Respiratory Distress Syndrome (ARDS). The early onset of non-cardiogenic edema and subsequent gas-exchange impairment caused by a severe inflammatory process known as cytokine storm is acute respiratory distress syndrome (ARDS). The existing strategy includes mechanical ventilation and glucocorticosteroid. However, they pose problems like diaphragm atrophy and down regulated immune response of the host in the lungs of patients with acute respiratory distress syndrome (ARDS), the nuclear regulatory factor NF-kappaB and TLR-4 is activated, which may contribute to increased expression of immune regulatory cytokines and other pro inflammatory mediators including IL-6 and TNF-alpha. Natural products play a pivotal role as it offers minimal and in some cases no toxicity. Albizia lebbeck is the folk language and is known for its anti-inflammatory properties. Targeting the above-mentioned receptors with bioactives from Albizia lebbeck would down regulate the signaling pathway and its associated mediators in ARDS. Through in- silico study including molecular docking, ADMET and Lipinski analysis, we are trying to narrow down the active phytoconstituent from Albizia lebbeck against ARDS.