Bryophyllum pinnatum Inhibits Angiotensin Converting Enzyme and Arginase Activities in Sodium Flouride Induced Hypertensive Rats

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2023-02-27 DOI:10.1080/10496475.2023.2184897

J. B. Adetunji, Abigail O. Agbolade, A. Iyoha, O. Adewale, Adeniyi S. Adefegha, Waliyat O. Salaudeen

引用次数: 1

Abstract

ABSTRACT Background: This study investigated the Bryophyllum pinnatum live plant fractions’ effects on the activities of angiotensin-converting-enzyme (ACE), arginase, blood pressure, and biochemical parameters in sodium fluoride (NaF)-induced hypertensive rats. The results revealed that diastolic blood pressure (DBP), systolic blood pressure (SBP), mean arterial pressure (MAP), heart rate (HR), and arginase activity were reduced with increased nitric oxide level compared to hypertensive rats. The aqueous fraction (AQF), n-hexane fraction (NHF), and ethyl acetate fraction (EAF) boosted superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) levels with reduction in malondialdehyde (MDA) of hypertensive-treated rats. NHF portends the capability to inhibit ACE and arginase activities and enhanced the antioxidant biomarkers.

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羽状苔藓对Flouride诱导的高血压大鼠血管紧张素转换酶和精氨酸酶活性的抑制作用

摘要背景：研究了羽状苔藓活植物组分对氟化钠（NaF）诱导的高血压大鼠血管紧张素转换酶（ACE）活性、精氨酸酶活性、血压和生化指标的影响。结果显示，与高血压大鼠相比，舒张压（DBP）、收缩压（SBP）、平均动脉压（MAP）、心率（HR）和精氨酸酶活性随着一氧化氮水平的升高而降低。水性组分（AQF）、正己烷组分（NHF）和乙酸乙酯组分（EAF）提高了高血压治疗大鼠的超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和还原型谷胱甘肽（GSH）水平，同时降低了丙二醛（MDA）。NHF具有抑制ACE和精氨酸酶活性并增强抗氧化生物标志物的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.