Genome Wide Characterization & Phylogenetic Analysis of TNF Genes in Homo Sapiens

Abstract

Tumor Necrosis Factor is very important inflammatory signaling unit that do an important role in immune system. It functions by attachment and stimulation of different receptor’s Cysteine Rich Domains (CDRs). A number of TNF receptors mediated factors have been identified having a major role in signal transduction pathways of TNF gene family. There are about 18 TNF homologues that are identified as a major cause of many disorders like cancer, Diabetes, AIDS and many other lethal inflammations. In this study the genome wide identification of TNF gene was done. Different tools and databases were used. Identification of conserved domains was done by using pfam and homology analysis showed that the TNF might be a member of TRAFs superfamily. Structural analysis of gene showed the number of introns and exons by a three-dimensional structure of TNF gene. The TNF gene family's exon-intron structure was found to be very similar in this study. The distribution of genes across chromosomes, on the other hand, was extremely varied. Collectively, the newly discovered genes can provide a wealth of information for manipulating the TNF genome to develop drugs and strategies to treat a variety of diseases.