The Efficacy of Miniaturized Repetitive Transcranial Magnetic Stimulation in Patients with Depression

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2019-08-01 DOI:10.9758/cpn.2019.17.3.409

Sangmin Lee, K. Jang, S. Yoon, J. Chae

{"title":"The Efficacy of Miniaturized Repetitive Transcranial Magnetic Stimulation in Patients with Depression","authors":"Sangmin Lee, K. Jang, S. Yoon, J. Chae","doi":"10.9758/cpn.2019.17.3.409","DOIUrl":null,"url":null,"abstract":"Objective The present study aimed to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) at a high frequency using a miniaturized device compared to standard rTMS and sham rTMS for the treatment of depression. Methods Fifty-four patients with depression were randomly assigned to either 15 days of miniaturized, standard, or sham rTMS. The stimulation consisted of 60 trains of 5 seconds at 10 Hz for 30 minutes. Clinical measures were assessed at baseline and on the final day of the stimulation. Results A repeated-measures analysis of variance revealed a significant main effect of time and a time by group interaction on Hamilton Rating Scale for Depression scores. There were no significant correlations between individual motor thresholds and changes of clinical outcomes. Our results revealed a significant reduction in the Hamilton Rating Scale for Depression in the miniaturized and standard groups compared to the sham group. Conclusion The antidepressant utility of miniaturized rTMS using subthreshold stimulation was comparable to that of standard stimulation.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"17 1","pages":"409 - 414"},"PeriodicalIF":2.4000,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Psychopharmacology and Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.9758/cpn.2019.17.3.409","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 12

Abstract

Objective The present study aimed to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) at a high frequency using a miniaturized device compared to standard rTMS and sham rTMS for the treatment of depression. Methods Fifty-four patients with depression were randomly assigned to either 15 days of miniaturized, standard, or sham rTMS. The stimulation consisted of 60 trains of 5 seconds at 10 Hz for 30 minutes. Clinical measures were assessed at baseline and on the final day of the stimulation. Results A repeated-measures analysis of variance revealed a significant main effect of time and a time by group interaction on Hamilton Rating Scale for Depression scores. There were no significant correlations between individual motor thresholds and changes of clinical outcomes. Our results revealed a significant reduction in the Hamilton Rating Scale for Depression in the miniaturized and standard groups compared to the sham group. Conclusion The antidepressant utility of miniaturized rTMS using subthreshold stimulation was comparable to that of standard stimulation.

查看原文本刊更多论文

小型重复性经颅磁刺激治疗抑郁症的疗效

目的本研究旨在与标准经颅磁刺激（rTMS）和假rTMS相比，评估使用小型化装置进行高频重复经颅磁激励（rTMS）治疗抑郁症的疗效。方法将54例抑郁症患者随机分为15天的小型化、标准化或假rTMS。刺激包括60列，5秒，10Hz，持续30分钟。在基线和刺激的最后一天评估临床测量。结果重复测量方差分析显示，时间和分组交互对汉密尔顿抑郁量表得分有显著的主要影响。个体运动阈值与临床结果变化之间没有显著相关性。我们的研究结果显示，与假手术组相比，小型化和标准化组的汉密尔顿抑郁评定量表显著降低。结论采用阈下刺激的微型rTMS的抗抑郁作用与标准刺激相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.