Polyol Pathway Shed Light on Non-Obstructive Azoospermia Testicular Sperm Extraction (TESE) Negative ROS Imbalance

Abstract

In our recent study regarding non-obstructive azoospermia by metabolomics technology, we clearly demonstrated that testicular sperm extraction negative patients are in extreme oxidative imbalance. With a reanalysis of our data and the integration of proteomics data, we found the Polyol pathway is up-regulated in non-obstructive azoospermia testicular sperm extraction negative patients. In this regard, we suggest the contribution of this biochemical pathway in the extreme oxidative imbalance of non-obstructive azoospermia testicular sperm extraction negative patients.