Favorable fatty acid composition in adipose tissue in healthy Iraqi- compared to Swedish-born men — a pilot study using MRI assessment

IF 3.5 4区生物学 Q2 ENDOCRINOLOGY & METABOLISM

Adipocyte Pub Date : 2022-03-16 DOI:10.1080/21623945.2022.2042963

L. Trinh, Karin G. Stenkula, L. Olsson, J. Svensson, P. Peterson, L. Bennet, S. Månsson

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引用次数: 1

Abstract

ABSTRACT Middle Eastern immigrants are at high-risk for insulin resistance. Fatty acid composition (FAC) plays an important role in the development of insulin resistance but has not been investigated in people of Middle Eastern ancestry. Here, the aim was to assess the FAC in visceral and subcutaneous adipose tissue (VAT and SAT) in healthy Iraqi- and Swedish-born men using a magnetic resonance imaging (MRI) method.This case-control study included 23 Iraqi- and 15 Swedish-born middle-aged men, without cardiometabolic disease. Using multi-echo MRI of the abdomen, the fractions of saturated, monounsaturated, and polyunsaturated fatty acids (fSFA, fMUFA, and fPUFA) were estimated in VAT and SAT. SAT was further analyzed in deep and superficial compartments (dSAT and sSAT). In all depots, fPUFA was significantly higher and fSFA significantly lower in Iraqi men, independently of age and BMI. In both Iraqi- and Swedish-born men, higher fPUFA and lower fMUFA were found in sSAT vs. dSAT. Among Iraqi men only, higher fPUFA and lower fMUFA were found in SAT vs. VAT.Iraqi-born men presented a more favorable abdominal FAC compared to Swedish-born men. This MRI method also revealed different FACs in different abdominal depots. Our results may reflect a beneficial FAC in Middle Eastern immigrants.

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健康伊拉克男性与瑞典出生男性脂肪组织中有利的脂肪酸成分——一项使用MRI评估的初步研究

中东移民是胰岛素抵抗的高危人群。脂肪酸组成(FAC)在胰岛素抵抗的发展中起重要作用，但尚未在中东血统人群中进行调查。在这里，目的是使用磁共振成像(MRI)方法评估伊拉克和瑞典出生的健康男性内脏和皮下脂肪组织(VAT和SAT)中的FAC。这项病例对照研究包括23名伊拉克和15名瑞典出生的中年男性，没有心脏代谢疾病。通过腹部多回波MRI，估计VAT和SAT中饱和、单不饱和和多不饱和脂肪酸(fSFA、fMUFA和fPUFA)的含量。进一步分析深层和浅表隔室(dSAT和sSAT)的SAT。在所有仓库中，伊拉克男性的fPUFA显著较高，fSFA显著较低，与年龄和BMI无关。在伊拉克和瑞典出生的男性中，sSAT与dSAT相比，fPUFA较高，fMUFA较低。仅在伊拉克男性中，在SAT和VAT中发现较高的fPUFA和较低的fMUFA。伊拉克出生的男性比瑞典出生的男性表现出更有利的腹部FAC。该MRI方法在腹部不同部位显示不同的FACs。我们的结果可能反映了中东移民中有益的FAC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Adipocyte Medicine-Histology

CiteScore

6.50

自引率

3.00%

发文量

审稿时长

32 weeks

期刊介绍： Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.