Laurus nobilis Linn. Inhibits Polyol Pathway Enzymes: Strategy for Managing Diabetic Complications

Q4 Pharmacology, Toxicology and Pharmaceutics

Current Enzyme Inhibition Pub Date : 2021-02-23 DOI:10.2174/1573408017666210223124126

H. Bankole, A. Fatai, Sulihat Motunrayo Aleshe, M. Kazeem, A. Kappo

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Abstract

The rising incidence of diabetic complications necessitate the continuous search for safer, cheaper and effective pharmacological agents. Polyol pathway is an underlying process implicated in the pathogenesis of diabetic complications. Inhibition of enzymes in the polyol pathway is a veritable means of ameliorating diabetic complications. This study evaluated the inhibitory potential of some spicy plants on the activities of polyol pathway enzymes (aldose reductase and sorbitol dehydrogenase). Aqueous extracts of Laurus nobilis (bay), Cinnamomum zeylanicum (cinnamon), Murraya koenigii (curry), Thymus vulgaris (thyme) and Curcuma longa (turmeric) were incubated with appropriate enzymes and substrates, and percentages inhibition determined. Results showed that bay extract had effective IC50 for inhibition of both aldose reductase (174.87 µg/mL) and sorbitol dehydrogenase (37.08 µg/mL). It also revealed that bay extract inhibited aldose reductase and sorbitol dehydrogenase in a non-competitive and competitive manner respectively. It is therefore concluded that bay extract effectively inhibited activities of polyol pathway enzymes, and may contribute to the amelioration of diabetic complications.

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月桂。抑制多元醇途径酶：糖尿病并发症的治疗策略

糖尿病并发症的发病率不断上升，需要不断寻找更安全、更便宜、更有效的药物。多元醇途径是糖尿病并发症发病机制中的一个潜在过程。抑制多元醇途径中的酶是改善糖尿病并发症的真正手段。本研究评估了一些辛辣植物对多元醇途径酶（醛糖还原酶和山梨醇脱氢酶）活性的抑制潜力。将月桂（月桂）、泽兰（肉桂）、锦鸡（咖喱）、百里香（百里香）和姜黄（姜黄）的水提取物与适当的酶和底物孵育，并测定抑制百分比。结果表明，海湾提取物对醛糖还原酶（174.87µg/mL）和山梨醇脱氢酶（37.08µg/mL。结果还表明，海湾提取物分别以非竞争和竞争的方式抑制醛糖还原酶和山梨醇脱氢酶。因此，海湾提取物有效抑制了多元醇途径酶的活性，可能有助于改善糖尿病并发症。

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来源期刊

Current Enzyme Inhibition Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.