Prevalence of nonalcoholic fatty liver disease in type 2 diabetes mellitus patients from the Eastern region of India

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-01 DOI:10.1016/j.deman.2023.100161

Anirban Sinha , Biswabandhu Bankura

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引用次数: 2

Abstract

Objective

The risk of nonalcoholic fatty liver disease (NAFLD) is increased significantly in individuals having Type 2 diabetes mellitus (T2DM) and the presence of T2DM enormously drives NAFLD progression. However, in clinical practice, it is overlooked despite the significant clinical effects of NAFLD in T2DM. Our study aimed to estimate the prevalence of NAFLD in T2DM patients from the eastern region of India.

Methods

This cross-sectional study assessed 132 T2DM patients for NAFLD. Anthropometry and lipid estimations were done in all the individuals. Hepatic fibrosis was diagnosed by transient elastography (TE) using a TOUCH 502 Fiber Scanner using M‑probe. A fibrosis score ≥ 11 kgpascals (kPa) was used to define advanced fibrosis (F3).

Results

Overall prevalence of NAFLD in T2DM patients was 57% (75/132 subjects) and the prevalence is higher in males (54.6%). Results showed that approximately 26% of patients with NAFLD will develop into NASH, among them 37.3% developed mild to moderate steatosis and 26.6% developed severe steatosis.

Conclusion

The prevalence of NAFLD is high in the eastern region of India, need for early diagnosis and treatment of NAFLD in T2DM. The use of TE with other serum markers can be helpful for the diagnosis of advanced fibrosis.

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印度东部地区2型糖尿病患者非酒精性脂肪肝患病率

目的2型糖尿病(T2DM)患者发生非酒精性脂肪性肝病(NAFLD)的风险显著增加，T2DM的存在极大地推动了NAFLD的进展。然而，在临床实践中，NAFLD在T2DM中具有重要的临床作用，但却被忽视。我们的研究旨在估计印度东部地区T2DM患者中NAFLD的患病率。方法本横断面研究评估了132例T2DM患者的NAFLD。对所有个体进行了人体测量和脂质评估。使用TOUCH 502纤维扫描仪使用M探针进行瞬时弹性成像(TE)诊断肝纤维化。纤维化评分≥11 kPa(千帕)定义晚期纤维化(F3)。结果T2DM患者NAFLD总体患病率为57%(75/132)，男性患病率较高(54.6%)。结果显示，约26%的NAFLD患者会发展为NASH，其中37.3%发展为轻中度脂肪变性，26.6%发展为重度脂肪变性。结论印度东部地区NAFLD患病率较高，T2DM患者需早期诊断和治疗。TE与其他血清标志物的联合使用有助于晚期纤维化的诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.