Aristolochia longa (Aristolochiaceae) Spice Alleviates Nickel-Induced Oxidative Stress and Biochemical Alterations in Rats

Ibtissam L, Samir D, Wiam Z
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Abstract

The objective of this work is to study the protective effect of Aristolochia longa against the variation of biochemical parameters and oxidative stress in rats exposed sub acutely to nickel. This is an experimental study carried out in the laboratory on 15 female Wistar rats divided into three groups (n=5), the first group of which serves as a control, the second group is contaminated with nickel, the third group is contaminated with nickel and treated with A. longa. Biochemical and oxidative stress parameters were analyzed on the rats of the various. The aqueous extract of A. longa included a variety of bioactive components, including polyphenols, saponins, terpenoids, glycosides, and flavonoids, according to phytochemical screening results, and nickel treatment resulted in a considerable increase in serum Urea, Uric acid, creatinine and GOT, GPT activities. The results obtained also reveal a bioaccumulation of Ni and an oxidative stress in group contaminated with nickel, with an increase in the level of hepatic Ni and a significant augmentation in the Kidney MDA and decrease in the level of GSH and the activity of tissue SOD. Treatment with A. longa improves biochemical parameters and reduces tissue nickel levels, with protection of organs against oxidative radical attacks induced by nickel. In conclusion, this study shows that treatment with A. longa induces a beneficial effect against the toxicity of nickel at the molecular and tissue level.
马兜铃(马兜铃科)香料减轻镍诱导的大鼠氧化应激和生化变化
本研究的目的是研究马兜铃对亚急性镍暴露大鼠生化参数变化和氧化应激的保护作用。这是一项在实验室对15只雌性Wistar大鼠进行的实验研究,分为三组(n=5),第一组作为对照,第二组用镍污染,第三组用镍和a.longa处理。分析了不同时期大鼠的生化和氧化应激参数。根据植物化学筛选结果,A.longa的水提取物含有多种生物活性成分,包括多酚、皂苷、萜类、糖苷和类黄酮,镍处理导致血清尿素、尿酸、肌酐和GOT、GPT活性显著增加。结果还表明,镍污染组存在镍的生物累积和氧化应激,肝脏镍水平升高,肾脏MDA显著增加,GSH水平和组织SOD活性降低。用A.longa治疗可以改善生化参数并降低组织镍水平,保护器官免受镍诱导的氧化自由基攻击。总之,本研究表明,A.longa治疗在分子和组织水平上对镍的毒性具有有益作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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