{"title":"Mechanosensitive Channels: History, Diversity, and Mechanisms","authors":"S. Sukharev, A. Anishkin","doi":"10.1134/S1990747822090021","DOIUrl":null,"url":null,"abstract":"<div><div><h3>\n <b>Abstract</b>—</h3><p>Mechanical forces are inseparable from most cellular functions. Cell division, contraction, and adhesion generate intrinsic forces in the cells, whereas perturbations in the environment such as osmotic shifts, mechanical pressure, shear, or sound represent the external forces that the cells gauge and respond to. Mechanosensitive (MS) ion channels, which are the fastest mechanotransducers, represent a polyphyletic group with vastly diverse structural designs. In this review we briefly outline the history of the field by presenting major findings in a nearly chronological order, describe structural features of different groups, and attempt to illustrate some common physical principles of their gating mechanisms.</p></div></div>","PeriodicalId":484,"journal":{"name":"Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology","volume":"16 4","pages":"291 - 310"},"PeriodicalIF":1.1000,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology","FirstCategoryId":"2","ListUrlMain":"https://link.springer.com/article/10.1134/S1990747822090021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 2
Abstract—
Mechanical forces are inseparable from most cellular functions. Cell division, contraction, and adhesion generate intrinsic forces in the cells, whereas perturbations in the environment such as osmotic shifts, mechanical pressure, shear, or sound represent the external forces that the cells gauge and respond to. Mechanosensitive (MS) ion channels, which are the fastest mechanotransducers, represent a polyphyletic group with vastly diverse structural designs. In this review we briefly outline the history of the field by presenting major findings in a nearly chronological order, describe structural features of different groups, and attempt to illustrate some common physical principles of their gating mechanisms.
期刊介绍：
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.
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