The Role of Lipid Domains and Physical Properties of Membranes in the Development of Age-Related Neurodegenerative Diseases

IF 1.1 Q4 CELL BIOLOGY

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology Pub Date : 2022-12-09 DOI:10.1134/S199074782209001X

V. D. Krasnobaev, O. V. Batishchev

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引用次数: 2

Abstract

A growing number of studies points to the relationship between the development of neurodegenerative diseases and the structure and lipid composition of neuronal membranes. One of the structural elements of cell membranes, to which special attention is paid in this regard, are liquid-ordered lipid domains, or rafts. The study of rafts and age-related changes in the lipid composition of neuronal cells is becoming increasingly relevant and is constantly being updated. In this review, we tried to highlight the possible role of the lipid component of cell membranes, their structure, and physicochemical characteristics in the development of diseases associated with aging. Evidence is reviewed that supports a possible role of rafts in diseases that over a long period of time lead to disruption of the functioning of neurons. There is a reason to believe that the therapeutic effects of various molecules, such as lysolipids and gangliosides, are due to their physicochemical properties and are realized indirectly, through their influence on the organization of lipid domains in membranes. As the role of lipid domains and, in general, the mechanisms of interaction and mutual influence of the lipid composition and disease development are more fully understood, this knowledge can be used to develop new therapeutic or preventive methods to combat diseases associated with aging.

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脂质结构域和膜的物理性质在年龄相关神经退行性疾病发展中的作用

越来越多的研究指出神经退行性疾病的发展与神经元膜的结构和脂质组成之间的关系。细胞膜的结构要素之一是液体有序的脂质结构域或筏，这是在这方面特别注意的。神经细胞脂质组成的筏和年龄相关变化的研究正变得越来越相关，并不断更新。在这篇综述中，我们试图强调细胞膜脂质成分，其结构和理化特性在衰老相关疾病发展中的可能作用。证据审查，支持筏在疾病的可能作用，在很长一段时间内导致神经元功能的破坏。有理由相信，溶脂类和神经节苷类等各种分子的治疗作用是由于它们的物理化学性质，并通过它们对膜中脂质结构域的组织的影响间接实现的。随着脂质结构域的作用以及脂质组成与疾病发展的相互作用和相互影响的机制得到更充分的了解，这些知识可用于开发新的治疗或预防方法来对抗与衰老相关的疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology CELL BIOLOGY-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.