Flaviviridae.

IF 3.2 4区医学 Q3 VIROLOGY

Intervirology Pub Date : 2020-02-02 DOI:10.32388/8ssgxf

E. G. Westaway, M. Brinton, Gaidamovich SYa, Marian C. Horzinek, A. Igarashi, L. Kääriäinen, D. K. Lvov, J. S. Porterfield, P. Russell, D. Trent

引用次数: 272

Abstract

The family Flaviviridae comprises the genus Flavivirus, which contains 65 related species and two possible members. They are small, enveloped RNA viruses (diameter 45 nm) with peplomers comprising a single glycoprotein E. Other structural proteins are designated C (core) and M (membrane-like). The single strand of RNA is infectious and has a molecular weight of about 4 X 10(6) and an m7G 'cap' at the 5' end but no poly(A) tract at the 3' end; it functions as the sole messenger. The gene sequence commences 5'-C-M-E.... The replication strategy and the mode of morphogenesis are distinct from those of the Togaviridae which are slightly larger and morphologically similar in some respects. Flaviviruses infect a wide range of vertebrates, and many are transmitted by arthropods.

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黄病毒科包括黄病毒属，包括65个相关种和两个可能的成员。它们是小的、包膜的RNA病毒(直径45 nm)，其聚聚体包含单个糖蛋白e。其他结构蛋白被命名为C(核心)和M(膜样)。单链RNA具有传染性，分子量约为4 × 10(6)，在5'端有一个m7G '帽'，但在3'端没有poly(a)链;它是唯一的信使。该基因序列从5'-C-M-E....开始它的复制策略和形态发生方式不同于托加维亚科的复制策略和形态发生方式，托加维亚科的复制策略和形态发生方式在某些方面是相似的。黄病毒可感染多种脊椎动物，其中许多是通过节肢动物传播的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intervirology 医学-病毒学

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Intervirology'' covers progress in both basic and clinical virus research, and aims to provide a forum for the various disciplines within virology. Issues publishing original papers alternate with thematic issues, focusing on clearly defined topics. This thematic concentration serves to make timely reviews, research reports and controversy easily accessible to both specialists in the field and those who want to keep track of the latest developments outside their own area of interest. In addition to original papers, regular issues publish short communications and letters to the editor to provide readers with a forum for the exchange of ideas and comments. The scope encompasses work on the molecular biology of human and animal viruses, including genome organization and regulation, and the structure and function of viral proteins. The pathogenesis, immunology, diagnosis, epidemiology, prophylaxis and therapy of viral diseases are considered.