Hydrogel-Crosslinked Microneedles Based on Microwave-Assisted Drying Method

IF 2 4区 工程技术 Q3 ENGINEERING, CHEMICAL
Dongyu Chen, Yu Zhang, Xiaoke Chen, Qiyao He, Tianwei Wu, Xiaoping Cao, Jing Liu, Xueqiu You
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引用次数: 1

Abstract

We present a method and several applications for the synthesis of hydrogel-crosslinked microneedle arrays utilizing microwave-assisted drying, ensuring a significant reduction in reaction preparation time while maintaining quality. We demonstrate the feasibility of drying hydrogels using microwaves and thus extend to crosslinked microneedle fabrication. Crosslinking was performed using 1,4-butanediol diglycidyl ether (BDDE) as a crosslinking agent. Infrared spectra of the microneedle arrays were measured with attenuated total reflection-Fourier transform infrared (ATR-FTIR). The surface morphology of the microneedle arrays was observed with scanning electron microscopy (SEM). The microneedle arrays were evaluated in terms of mechanical strength, swelling kinetics, rheological properties, degradation rate, and glucose iontophoresis. The results show that this method can shorten the reaction preparation time by 5 hours, and the prepared crosslinked microneedle array has better crosslinking efficiency, swelling effect, and greater mechanical strength than traditional methods.
基于微波干燥法的水凝胶交联微针
我们提出了一种利用微波辅助干燥合成水凝胶交联微针阵列的方法和几种应用,确保在保持质量的同时显著缩短反应制备时间。我们证明了使用微波干燥水凝胶的可行性,从而扩展到交联微针的制造。使用1,4-丁二醇二缩水甘油醚(BDDE)作为交联剂进行交联。用衰减全反射傅立叶变换红外光谱(ATR-FTIR)测量微针阵列的红外光谱。用扫描电子显微镜(SEM)观察了微针阵列的表面形貌。对微针阵列的机械强度、溶胀动力学、流变特性、降解速率和葡萄糖离子电渗进行了评估。结果表明,该方法可将反应制备时间缩短5小时,制备的交联微针阵列具有比传统方法更好的交联效率、溶胀效果和更大的机械强度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advances in Polymer Technology
Advances in Polymer Technology 工程技术-高分子科学
CiteScore
5.50
自引率
0.00%
发文量
70
审稿时长
9 months
期刊介绍: Advances in Polymer Technology publishes articles reporting important developments in polymeric materials, their manufacture and processing, and polymer product design, as well as those considering the economic and environmental impacts of polymer technology. The journal primarily caters to researchers, technologists, engineers, consultants, and production personnel.
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