A Meta-Analysis of the Effectiveness of Vitamin C in the Prevention and Treatment of Childhood Upper Respiratory Tract Infections

临床护理研究 Pub Date : 2023-01-05 DOI:10.26689/jcnr.v7i1.4403

Haitham Saeed, Mohamed E A Abdelrahim

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引用次数: 1

Abstract

Background: The effectiveness of vitamin C in the prevention and treatment of pediatric upper respiratory tract infections was evaluated in a meta-analysis. Methods: A total 2,573 children with upper respiratory tract infections were included in the meta-analysis, 1,280 of whom received vitamin C and 1,293 who received control medication. The analysis of findings related to the studies included was done through random or fixed effects model to determine whether vitamin C supplementation could stop and control upper respiratory tract infections in children using mean difference (MD) with 95% confidence intervals (CIs). Results: On average, vitamin C-treated children had fewer upper respiratory tract infection bouts, their illness lasted shorter (MD -0.84; 95% CI -1.47 to -0.20, P = 0.009), and they were less contagious than the control. Conclusions: The number of episodes and illness duration of upper respiratory tract-infected pediatric subjects were considerably reduced in the intervention group (vitamin C) compared to the control. Due to the small sample size in four of 11 studies and the limited number of studies included for comparison, the outcomes should be carefully examined.

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维生素C防治儿童上呼吸道感染疗效的Meta分析

背景：在一项荟萃分析中评估了维生素C在预防和治疗儿童上呼吸道感染中的有效性。方法：共有2573名上呼吸道感染儿童纳入荟萃分析，其中1280人接受维生素C治疗，1293人接受对照药物治疗。通过随机或固定效应模型对与纳入的研究相关的结果进行分析，以确定补充维生素C是否可以使用95%置信区间的平均差（MD）来阻止和控制儿童上呼吸道感染。结果：平均而言，维生素C治疗的儿童上呼吸道感染发作次数较少，疾病持续时间较短（MD-0.84；95%CI-1.47至-0.20，P=0.009），且其传染性低于对照组。结论：与对照组相比，干预组（维生素C）的上呼吸道感染儿童受试者的发作次数和病程显著减少。由于11项研究中有4项的样本量较小，且用于比较的研究数量有限，因此应仔细检查结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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临床护理研究

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236