A Case of Mycobacterium avium Complex Vertebral Osteomyelitis in a Patient With Human Immunodeficiency Virus

IF 0.4 Q4 INFECTIOUS DISEASES

Infectious Diseases in Clinical Practice Pub Date : 2023-07-01 DOI:10.1097/ipc.0000000000001283

Kirtan Amin, Yasmin Rosshandler, J. Norris, Folasade Arinze

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Abstract

Mycobacterium avium complex (MAC) infection is one of the most common bacterial opportunistic infections in persons living with human immunodeficiency virus (PLWH). Mycobacterium avium complex infections are caused by either M. avium or Mycobacterium intracellulare, which are nontuberculous mycobacterial species. Mycobacterium avium complex is prevalent in soil, water, and animals in the environment. Mycobacterium avium complex infections are commonly seen in persons with CD4 counts less than 50 cells/μL and are the most common cause of disseminated disease in immunocompromised patients. Vertebral osteomyelitis caused by MAC, however, remains uncommon in PLWH, with few cases reported in the literature (Lancet Infect Dis. 2004;4:557–565; Infect Dis Clin Pract. 2001;10:17–20). We present a case of vertebral osteomyelitis secondary to MAC in a person with human immunodeficiency virus and compare 10 other cases reported in the literature. Our case also highlights the importance of resuming secondary MAC prophylaxis when CD4 counts decline below 100 cells/μL in PLWH.

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禽分枝杆菌复合椎体骨髓炎伴人类免疫缺陷病毒1例

禽分枝杆菌复合体（MAC）感染是人类免疫缺陷病毒（PLWH）感染者最常见的细菌机会性感染之一。禽分枝杆菌复合感染是由禽分枝杆菌或细胞内分枝杆菌引起的，它们是非结核分枝杆菌。禽分枝杆菌复合体在土壤、水和环境中的动物中普遍存在。禽分枝杆菌复合体感染常见于CD4计数低于50个细胞/μL的人，是免疫功能低下患者中传播性疾病的最常见原因。然而，MAC引起的脊椎骨髓炎在PLWH中仍然不常见，文献中很少报道病例（Lancet Infect Dis.2004；4:557-565；Infect Dis Clin Pract.2001；10:17-20）。我们报告了一例人类免疫缺陷病毒感染者继发于MAC的脊椎骨髓炎，并比较了文献中报道的其他10例。我们的病例还强调了当PLWH中CD4计数降至100细胞/μL以下时，恢复二次MAC预防的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Diseases in Clinical Practice INFECTIOUS DISEASES-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Medical professionals seeking an infectious diseases journal with true clinical value need look no further than Infectious Diseases in Clinical Practice. Here, clinicians can get full coverage consolidated into one resource, with pertinent new developments presented in a way that makes them easy to apply to patient care. From HIV care delivery to Hepatitis C virus testing…travel and tropical medicine…and infection surveillance, prevention, and control, Infectious Diseases in Clinical Practice delivers the vital information needed to optimally prevent and treat infectious diseases. Indexed/abstracted in: EMBASE, SCOPUS, Current Contents/Clinical Medicine