Serological testing for Trichinella infection in animals and man: Current status and opportunities for advancements

IF 2.9 Q2 PARASITOLOGY

Food and Waterborne Parasitology Pub Date : 2022-06-01 DOI:10.1016/j.fawpar.2022.e00165

María Ángeles Gómez-Morales, Simona Cherchi, Alessandra Ludovisi

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引用次数: 3

Abstract

Serological tests are widely used for the detection of Trichinella spp. infections in animals and humans. Despite some limitations, (such as low sensitivity in the early period after infection) ELISA and western blot testing have demonstrated good performance when excretory/secretory products from muscle larvae are used as antigens in agreement with the International Commission on Trichinellosis. Over recent decades, considerable progress has been made in the characterization of Trichinella-derived molecules in the hope of improving diagnosis, mainly during the early days post infection. Despite these efforts, validated tests using characterized antigens for early diagnosis are still not available. However, combining currently available sero-diagnostic tools with clinical and epidemiological data provides valuable information on Trichinella infections in humans and animals as shown in this review.

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动物和人类旋毛虫感染的血清学检测：现状和发展机遇

血清学试验广泛用于检测动物和人类中的旋毛虫感染。尽管存在一些局限性(如感染后早期敏感性较低)，但与国际旋毛虫病委员会一致，ELISA和western blot检测在将肌肉幼虫的排泄/分泌产物用作抗原时表现良好。近几十年来，在旋毛虫衍生分子的表征方面取得了相当大的进展，希望改善诊断，主要是在感染后的早期。尽管做出了这些努力，但仍然没有使用特征抗原进行早期诊断的有效测试。然而，将目前可用的血清诊断工具与临床和流行病学数据相结合，可以提供有关人类和动物旋毛虫感染的宝贵信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food and Waterborne Parasitology Immunology and Microbiology-Parasitology

CiteScore

5.10

自引率

4.00%

发文量

审稿时长

13 weeks

期刊介绍： Food and Waterborne Parasitology publishes high quality papers containing original research findings, investigative reports, and scientific proceedings on parasites which are transmitted to humans via the consumption of food or water. The relevant parasites include protozoa, nematodes, cestodes and trematodes which are transmitted by food or water and capable of infecting humans. Pertinent food includes products of animal or plant origin which are domestic or wild, and consumed by humans. Animals and plants from both terrestrial and aquatic sources are included, as well as studies related to potable and other types of water which serve to harbor, perpetuate or disseminate food and waterborne parasites. Studies dealing with prevalence, transmission, epidemiology, risk assessment and mitigation, including control measures and test methodologies for parasites in food and water are of particular interest. Evidence of the emergence of such parasites and interactions among domestic animals, wildlife and humans are of interest. The impact of parasites on the health and welfare of humans is viewed as very important and within scope of the journal. Manuscripts with scientifically generated information on associations between food and waterborne parasitic diseases and lifestyle, culture and economies are also welcome. Studies involving animal experiments must meet the International Guiding Principles for Biomedical Research Involving Animals as issued by the Council for International Organizations of Medical Sciences.