Poria cocos-derived carbon dots for cellular imaging, free radical scavenging and pH sensing

IF 5.1 3区材料科学 Q2 MATERIALS SCIENCE, COATINGS & FILMS

Diamond and Related Materials Pub Date : 2023-08-01 DOI:10.1016/j.diamond.2023.110121

Song Yuan , Yuanping Luo , Yuxiang Jiang , Wenjun Xu , Beijun Cheng , Zhili Peng

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引用次数: 6

Abstract

Green, economical preparation of carbon dots (CDs) from traditional Chinese herbal medicine Poria cocos via a one-step hydrothermal treatment was reported. The CDs exhibited excellent aqueous dispersibility, superior photoluminescence (PL) property and low cytotoxicity. Taking advantage of these properties, CDs were demonstrated as excellent multicolor bioimaging agents for the cellular imaging of MDA-MB-435S cells, with main distributions in the cell membranes and cytoplasm. Moreover, the CDs also exhibited good radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) thanks to their inheritance of characteristic functionalities from Poria cocos. Lastly, our study also shown that the PL of CDs was reversibly sensitive to pH in the range of 4.0 and 9.0, and a highly sensitive pH-sensing assay was developed exploiting this phenomenon. In summary, the study opened up new development paths for the modernization and vitalization of traditional Chinese medicine in biomedical research.

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用于细胞成像、清除自由基和pH传感的茯苓衍生碳点

以中草药茯苓为原料，采用一步水热法制备了绿色、经济的碳点。CDs具有优异的水分散性、优异的光致发光性能和较低的细胞毒性。利用这些特性，CDs被证明是MDA-MB-435S细胞成像的优秀多色生物显像剂，主要分布在细胞膜和细胞质中。此外，CDs还具有良好的DPPH自由基清除活性，这是由于它们继承了茯苓的特征功能。最后，我们的研究还表明，CDs的PL对pH值在4.0和9.0范围内的可逆敏感，并利用这一现象建立了高灵敏度的pH感应实验。综上所述，本研究为中医药在生物医学研究中的现代化与振兴开辟了新的发展路径。

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来源期刊

Diamond and Related Materials 工程技术-材料科学：综合

CiteScore

6.00

自引率

14.60%

发文量

702

审稿时长

2.1 months

期刊介绍： DRM is a leading international journal that publishes new fundamental and applied research on all forms of diamond, the integration of diamond with other advanced materials and development of technologies exploiting diamond. The synthesis, characterization and processing of single crystal diamond, polycrystalline films, nanodiamond powders and heterostructures with other advanced materials are encouraged topics for technical and review articles. In addition to diamond, the journal publishes manuscripts on the synthesis, characterization and application of other related materials including diamond-like carbons, carbon nanotubes, graphene, and boron and carbon nitrides. Articles are sought on the chemical functionalization of diamond and related materials as well as their use in electrochemistry, energy storage and conversion, chemical and biological sensing, imaging, thermal management, photonic and quantum applications, electron emission and electronic devices. The International Conference on Diamond and Carbon Materials has evolved into the largest and most well attended forum in the field of diamond, providing a forum to showcase the latest results in the science and technology of diamond and other carbon materials such as carbon nanotubes, graphene, and diamond-like carbon. Run annually in association with Diamond and Related Materials the conference provides junior and established researchers the opportunity to exchange the latest results ranging from fundamental physical and chemical concepts to applied research focusing on the next generation carbon-based devices.