The Inhibition of Glutathione S-Transferases and Butyrylcholinesterase by Antidepressants: A Mini-Review on Enzyme-Drug Interaction

Abstract

Compromises in the cellular enzymatic defense barrier can increase the duration of exposure to electrophiles and the severity of toxicity they may incur. In this mini-review, we discuss the inhibition of the enzymatic defense systems by different antidepressants commonly prescribed worldwide as well as herbal products used for various forms of depression. Our work is primarily focused on the interactions of two prominent biotransformation enzyme systems, namely glutathione S-transferases and cholinesterases, with tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and hypericin. The outcomes of available published studies and their implications in health and disease are discussed here in depth.