Cardioprotective Effect of Low Molecular Weight (Below 5 kDa) Fraction of Cattle Cord Blood Cryohemolysate

Q4 Medicine

Problems of Cryobiology and Cryomedicine Pub Date : 2022-09-30 DOI:10.15407/cryo32.03.206

I. Shcheniavsky, I. Kovalenko, O. Gulevsky

引用次数: 0

Abstract

In this report, we have studied a cardioprotective effect of low molecular weight (below 5 kDa) fraction derived from cattle cord blood in a rat model of infarction-like cardiovasopathy. The myocardial infarction development was initiated in the animals, maintained for two months on a diet with excessive intake of fat, calcium and sodium salts, by making hypoxia-hypercapnia in them. The use of this model allowed inducing the infarction-like cardiovasopathy, comparable by many respects with the clinical picture of myocardial infarction, which was confirmed by electrocardiography, enzyme-linked immunosorbent assay and histological analysis. Preliminary administration of low molecular weight (below 5 kDa) fraction of cattle cord blood, as well as Actovegin did not prevent the heart attack, but increased the endurance of rats to hypoxia-hypercapnia and reduced the damage rate to myocardium. A preventive administration of low molecular weight fraction of cord blood was proven to mitigate the risk of hypoxia-induced damages to myocardium.

查看原文本刊更多论文

牛脐血冷冻溶血液低分子量（5kDa以下）组分的心脏保护作用

在本报告中，我们研究了从牛脐带血中提取的低分子量（低于5kDa）组分在梗死样心血管病大鼠模型中的心脏保护作用。心肌梗死的发生始于动物，通过使其缺氧高碳酸血症，在摄入过量脂肪、钙和钠盐的饮食中维持两个月。该模型的使用可以诱导类似梗死的心血管病，在许多方面与心肌梗死的临床表现相当，心电图、酶联免疫吸附测定和组织学分析证实了这一点。牛脐血低分子量（低于5kDa）组分以及Actovegin的初步给药并不能预防心脏病发作，但能提高大鼠对缺氧高碳酸血症的耐受性，降低心肌损伤率。脐血低分子量组分的预防性给药已被证明可以减轻缺氧诱导的心肌损伤的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Problems of Cryobiology and Cryomedicine Medicine-Medicine (miscellaneous)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： The Journal publishes the reviews and original papers on cryobiological and cryomedical research, in particular the elucidation of mechanisms of injuries occurring in biological objects and caused by the influence of low and ultra low temperatures; natural resistance of biologicals to cold and their recovery post effect; the development of effective methods of cryoprotection and technology of storage of biological resources under hypothermic and ultra low temperatures, application of hypothermia, cryotherapy and cryopreserved biologicals for treating various pathologies; cell and tissue based therapies and other issues of low-temperature biology and medicine, as well as development of devices and equipment for low temperature biology and medicine. The journal covers all topics related to low temperature biology, medicine and engineering. These include but are not limited to: low temperature storage of biologicals (human, animal or plant cells, tissues, and organs), including preparation for storage, thawing/warming, cell and tissue culturing etc. response of biologicals to low temperature; cold adaptation of animals and plants; utilisation of low temperature in medicine; experimental and clinical transplantation, cell and tissue based therapies; developing of cryobiological and cryomedical devices; organisation and functioning of low temperature banks etc.