Analysis of serum gastric function and Helicobacter pylori infection in patients with gastric hyperplastic polyps and gastric fundic gland polyps

中国综合临床 Pub Date : 2019-09-01 DOI:10.3760/CMA.J.ISSN.1008-6315.2019.05.017

Menglan Wang, Junlian Liu, Yanhong Wang, Rui Zhong, S. Fei

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引用次数: 0

Abstract

Objective To analyze the serum gastric function and Helicobacter pylori (HP) infection in patients with gastric hyperplastic polyps and gastric fundic gland polyps. Methods From December 2017 to December 2018, 135 patients with gastric polyps and pathologically confirmed gastric hyperplastic polyps and gastric fundic gland polyps were enrolled in the hospital of Xuzhou Medical University.Among them, 68 patients with hyperplastic polyps, 67 cases of the gastric fundic gland polyps.Serum Hp antibodies (UreA, UreB, VacA, CagA antibodies) were qualitatively detected by immunoblotting.Eighty patients with chronic superficial gastritis were selected as the control group.Three groups of serum pepsinogen-I (PG-I), pepsinogen-Ⅱ (PG-Ⅱ), gastrin were detected by enzyme-linked immunosorbent assay (ELISA). Gastrin-17(G-17) and calculate PGⅠ and PGⅡ ratio(PGR). Results The levels of serum PGⅡ (13.13(8.15, 20.30) μg /L) and G17 (8.44(3.72, 27.17) pmol/L) in the gastric hyperplastic polyp group were higher than those in the control group (9.16(5.56, 15.14) μg/L and 1.83(0.87, 5.95) pmol/L) (P<0.05), and the PGR level was lower than the control group (P<0.05); serum PGI (120.12(86.72, 174.70) μg/L), PGII (11.92(7.27, 22.26) μg/L), G17 (5.68(1.79, 14.65) pmol/L) in the gastric fundic gland polyp group was higher than the control group ((101.32(79.17, 131.33) μg /L, 9.16(5.56, 15.14) μg /L, 1.83(0.87, 5.95) pmol/L)(P均<0.05)) (P<0.05); serum G17 (8.44(3.72, 27.17) pmol/L) level in gastric hyperplastic polyp group was higher than gastric fundus polyp group (5.68(1.79, 14.65) pmol/L) (P<0.05); Hp infection rate in gastric hyperplastic polyp group61.76%(42/68)was higher than that in the gastric fundic gland polyp group40.30%(27/67) (P<0.05), and type I Hp was the main one (P<0.05). The serum PGⅡ and G17 levels in the gastric hyperplastic polyp group were higher than those of Hp negative (all P<0.05). There were no significant differences in serum PGI, PGⅡ, G17, and PGR levels between the HP-positive and negative-positive patients in the gastric fundus polyp group.The serum PGI and PGR levels in the hypertrophic polyp group were higher than those in the HPⅡ type (all P<0.05). There was no significant difference in the levels of serum PGⅠ, PGⅡ, G17, and PGR between the gastric fundic gland polyps group and the type Ⅱ. Conclusion Serum PG and G17 levels in patients with gastric hypertrophic polyps and gastric fundic gland polyps are higher than those in patients with chronic superficial gastritis.Patients with gastric hyperplastic polyps have higher HP infection rate and abnormal gastric function than gastric fundic gland polyps. Key words: Gastric hyperplastic polyp; Gastric fundus polyp; Helicobacter pylori; pepsinogen; Gastrin

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胃增生性息肉和胃底腺息肉患者血清胃功能及幽门螺杆菌感染分析

目的分析胃增生性息肉和胃底腺息肉患者血清胃功能及幽门螺杆菌（HP）感染情况。方法2017年12月至2018年12月，徐州医科大学医院收治胃息肉及经病理证实的胃增生性息肉、胃底腺息肉135例，其中增生性息肉68例，胃底腺腺瘤67例。通过免疫印迹法对血清Hp抗体（UreA、UreB、VacA、CagA抗体）进行定性检测。选择80例慢性浅表性胃炎患者作为对照组。采用酶联免疫吸附法（ELISA）检测三组血清胃蛋白酶原-Ⅰ（PG-I）、胃蛋白酶原-Ⅱ（PG-Ⅱ）和胃泌素。Gastrin-17（G-17），计算PGⅠ和PGⅡ比值（PGR）。结果胃增生性息肉组血清PGⅡ（13.13（8.15，20.30）μg/L）和G17（8.44（3.72，27.17）pmol/L）高于对照组（9.16（5.56，15.14）μg/L和1.83（0.87，5.95）pmol/L）（P<0.05），PGR水平低于对照组（P<0.05）；胃底腺息肉组血清PGI（120.12（86.72，174.70）μg/L）、PGII（11.92（7.27，22.26）μg/L）、G17（5.68（1.79，14.65）pmol/L）高于对照组（101.32（79.17，131.33）μg/L、9.16（5.56，15.14）μg/L和1.83（0.87，5.95）pmmol/L）（P均<0.05））（P<0.05）；胃增生性息肉组血清G17（8.44（3.72，27.17）pmol/L）高于胃底息肉组（5.68（1.79，14.65）pmol/L）（P＜0.05）；胃增生性息肉组Hp感染率61.76%（42/68）高于胃底腺息肉组40.30%（27/67）（P＜0.05），以Ⅰ型Hp为主（P＜0.01），以及胃底息肉组HP阳性和阴性阳性患者之间的PGR水平。肥厚性息肉组血清PGI、PGR水平均高于HPⅡ型（P均<0.05），胃底腺息肉组与Ⅱ型组血清PGⅠ、PGⅡ、G17和PGR水平差异无统计学意义。结论胃肥厚性息肉和胃底腺息肉患者血清PG和G17水平高于慢性浅表性胃炎患者。胃增生性息肉患者HP感染率和胃功能异常均高于胃底腺息肉。关键词：胃增生性息肉；胃底息肉；幽门螺杆菌；胃蛋白酶原；胃泌素

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来源期刊

中国综合临床

CiteScore

0.10

自引率

0.00%

发文量

16855

期刊介绍： Clinical Medicine of China is an academic journal organized by the Chinese Medical Association (CMA), which mainly publishes original research papers, reviews and commentaries in the field. Clinical Medicine of China is a source journal of Peking University (2000 and 2004 editions), a core journal of Chinese science and technology, an academic journal of RCCSE China Core (Extended Edition), and has been published in Chemical Abstracts of the United States (CA), Abstracts Journal of Russia (AJ), Chinese Core Journals (Selection) Database, Chinese Science and Technology Materials Directory, Wanfang Database, China Academic Journal Database, JST Japan Science and Technology Agency Database (Japanese) (2018) and other databases.