Electron Beam Powder Bed Fusion of Ti-48Al-2Cr-2Nb Open Porous Scaffold for Biomedical Applications: Process Parameters, Adhesion, and Proliferation of NIH-3T3 Cells.

IF 2.3 4区工程技术 Q3 ENGINEERING, MANUFACTURING

3D Printing and Additive Manufacturing Pub Date : 2024-02-01 Epub Date: 2024-02-15 DOI:10.1089/3dp.2022.0108

Manuela Galati, Maria Laura Gatto, Nora Bloise, Lorenzo Fassina, Abdollah Saboori, Livia Visai, Paolo Mengucci, Luca Iuliano

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引用次数: 0

Abstract

Titanium aluminide (TiAl)-based intermetallics, especially Ti-48Al-2Cr-2Nb, are a well-established class of materials for producing bulky components using the electron beam powder bed fusion (EB-PBF) process. The biological properties of Ti-48Al-2Cr-2Nb alloy have been rarely investigated, specifically using complex cellular structures. This work investigates the viability and proliferation of NIH-3T3 fibroblasts on Ti-48Al-2Cr-2Nb dodecahedral open scaffolds manufactured by the EB-PBF process. A process parameter optimization is carried out to produce a fully dense part. Then scaffolds are produced and characterized using different techniques, including scanning electron microscopy and X-ray tomography. In vitro viability tests are performed with NIH-3T3 cells after incubation for 1, 4, and 7 days. The results show that Ti-48Al-2Cr-2Nb represents a promising new entry in the biomaterial field.

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用于生物医学应用的Ti-48Al-2Cr-2Nb开放多孔支架的电子束粉末床融合:工艺参数，粘附和NIH-3T3细胞的增殖

铝化钛（TiAl）基金属间化合物，特别是 Ti-48Al-2Cr-2Nb 是一种成熟的材料，可用于使用电子束粉末床熔融（EB-PBF）工艺生产大型部件。人们很少研究 Ti-48Al-2Cr-2Nb 合金的生物特性，特别是使用复杂的细胞结构。这项工作研究了通过 EB-PBF 工艺制造的 Ti-48Al-2Cr-2Nb 十二面体开放式支架上 NIH-3T3 成纤维细胞的活力和增殖情况。对工艺参数进行了优化，以生产出完全致密的部件。然后使用不同的技术（包括扫描电子显微镜和 X 射线断层扫描）对支架进行生产和表征。在培养 1、4 和 7 天后，用 NIH-3T3 细胞进行体外活力测试。结果表明，Ti-48Al-2Cr-2Nb 是生物材料领域中一种前景广阔的新材料。

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来源期刊

3D Printing and Additive Manufacturing Materials Science-Materials Science (miscellaneous)

CiteScore

6.00

自引率

6.50%

发文量

126

期刊介绍： 3D Printing and Additive Manufacturing is a peer-reviewed journal that provides a forum for world-class research in additive manufacturing and related technologies. The Journal explores emerging challenges and opportunities ranging from new developments of processes and materials, to new simulation and design tools, and informative applications and case studies. Novel applications in new areas, such as medicine, education, bio-printing, food printing, art and architecture, are also encouraged. The Journal addresses the important questions surrounding this powerful and growing field, including issues in policy and law, intellectual property, data standards, safety and liability, environmental impact, social, economic, and humanitarian implications, and emerging business models at the industrial and consumer scales.