The Repurposed ACE2 Inhibitors: SARS-CoV-2 Entry Blockers of Covid-19

IF 7.1 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Topics in Current Chemistry Pub Date : 2021-10-08 DOI:10.1007/s41061-021-00353-7

Iqrar Ahmad, Rahul Pawara, Sanjay Surana, Harun Patel

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引用次数: 29

Abstract

The highly infectious disease COVID-19 is induced by SARS-coronavirus 2 (SARS-CoV-2), which has spread rapidly around the globe and was announced as a pandemic by the World Health Organization (WHO) in March 2020. SARS-CoV-2 binds to the host cell’s angiotensin converting enzyme 2 (ACE2) receptor through the viral surface spike glycoprotein (S-protein). ACE2 is expressed in the oral mucosa and can therefore constitute an essential route for entry of SARS-CoV-2 into hosts through the tongue and lung epithelial cells. At present, no effective treatments for SARS-CoV-2 are yet in place. Blocking entry of the virus by inhibiting ACE2 is more advantageous than inhibiting the subsequent stages of the SARS-CoV-2 life cycle. Based on current published evidence, we have summarized the different in silico based studies and repurposing of anti-viral drugs to target ACE2, SARS-CoV-2 S-Protein: ACE2 and SARS-CoV-2 S-RBD: ACE2. This review will be useful to researchers looking to effectively recognize and deal with SARS-CoV-2, and in the development of repurposed ACE2 inhibitors against COVID-19.

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重组ACE2抑制剂:Covid-19的SARS-CoV-2进入阻断剂

COVID-19是由sars -冠状病毒2 (SARS-CoV-2)引起的高传染性疾病，该疾病在全球迅速传播，并于2020年3月被世界卫生组织(世卫组织)宣布为大流行。SARS-CoV-2通过病毒表面刺突糖蛋白(s蛋白)与宿主细胞的血管紧张素转换酶2 (ACE2)受体结合。ACE2在口腔黏膜中表达，因此可能是SARS-CoV-2通过舌头和肺上皮细胞进入宿主的重要途径。目前，还没有针对SARS-CoV-2的有效治疗方法。通过抑制ACE2来阻止病毒进入比抑制SARS-CoV-2生命周期的后续阶段更有利。基于目前已发表的证据，我们总结了不同的基于计算机的研究和针对ACE2、SARS-CoV-2 S-Protein: ACE2和SARS-CoV-2 S-RBD: ACE2的抗病毒药物的重新用途。这篇综述将有助于研究人员有效识别和处理SARS-CoV-2，以及开发针对COVID-19的重新用途的ACE2抑制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Current Chemistry Chemistry-General Chemistry

CiteScore

13.70

自引率

1.20%

发文量

期刊介绍： Topics in Current Chemistry is a journal that presents critical reviews of present and future trends in modern chemical research. It covers all areas of chemical science, including interactions with related disciplines like biology, medicine, physics, and materials science. The articles in this journal are organized into thematic collections, offering a comprehensive perspective on emerging research to non-specialist readers in academia or industry. Each review article focuses on one aspect of the topic and provides a critical survey, placing it in the context of the collection. Selected examples highlight significant developments from the past 5 to 10 years. Instead of providing an exhaustive summary or extensive data, the articles concentrate on methodological thinking. This approach allows non-specialist readers to understand the information fully and presents the potential prospects for future developments.