COMPUTATIONAL SIMULATION OF THE INTERACTION AMONG AUTOREGULATION MECHANISMS REGULATING CEREBRAL BLOOD FLOW RATE IN SYSTOLIC HEART FAILURE

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-12-31 DOI:10.1142/s0218339023500043

Surhan Bozkurt, U. E. Ayten

引用次数: 0

Abstract

In this study, a lumped parameter model which includes systemic circulation, cerebral blood vessels, systemic arteriolar resistance control, heart rate control, cerebral autoregulation mechanisms and cerebral CO2 reactivity was developed to simulate healthy and heart failure conditions. In the healthy cardiovascular system model, the results were obtained with all control mechanisms connected to the model. Whilst heart failure cases were simulated, all control mechanisms were removed from the model. Then, cerebral autoregulation and cerebral CO2 reactivity mechanisms were connected to the model. Lastly, systemic arteriolar resistance and heart rate control mechanisms were connected to the model. Also, Monte Carlo Analysis was performed to determine the range of parameters controlled for simulations of healthy and heart failure conditions. The results showed that blood flow rate in cerebral circulation can be simulated more accurately by modeling interaction among autoregulatory mechanisms rather than studying separately.

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收缩期心力衰竭脑血流速率自动调节机制相互作用的计算模拟

本研究建立了包括体循环、脑血管、全身小动脉阻力控制、心率控制、脑自动调节机制和脑CO2反应性在内的集总参数模型，模拟健康和心力衰竭情况。在健康心血管系统模型中，所有的控制机制都与模型相关。在模拟心力衰竭病例时，从模型中删除了所有控制机制。然后，将脑自动调节和脑CO2反应机制与模型联系起来。最后，将全身动脉阻力和心率控制机制与模型联系起来。此外，还进行了蒙特卡罗分析，以确定用于模拟健康和心力衰竭状况的控制参数范围。结果表明，与单独研究脑循环血流速率相比，通过相互作用的模型来模拟脑循环血流速率更为准确。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.