In silico and in vitro investigations of antihelmintic activities of selected approved drugs

Abstract

We investigated the binding affinities of some approved drugs to ascaris suum Mitochondrial Rhodoquinol Fumarate Reductase (MRFR), an essential enzyme for ascaris survival, and the possibility of repurposing these drugs as antihelmintic agents using In silico molecular docking and in vitro paralysis and mortality times of fifteen selected front runners.