{"title":"Restorative Effects of Capsaicin Encapsulated Chitosan Nanoparticles on Chemically-Induced Hormone Receptor-Positive Mammary Carcinoma in Sprague-Dawley Rats","authors":"D. Kalaiyarasi","doi":"10.21786/bbrc/15.1.39","DOIUrl":null,"url":null,"abstract":"The clinical use of capsaicin has been confined due to its low-grade solubility and frail bioavailability. So, we examined the impact of capsaicin encapsulated chitosan nanoparticles (CAP@CS-NP) on chemically induced hormone receptor-positive mammary carcinoma. The mammary tumor was induced by a single dose of 7,12-Dimethylbenz(a)anthracene (DMBA) 25mg/kg b.wt. injected subcutaneously near the mammary gland. After 7 weeks, CAP@CS-NP 4mg/kg b.wt. was administered orally to tumor-bearing rats. Furthermore, sex hormones levels, ER and PR expression, mast cell population, and molecular docking studies were carried out. Tumor-bearing rats flashed significantly hoisted levels of sex hormones, mast cell population, ER, and PR expression. Administration of CAP@CS-NP 4mg/kg b.wt. restored the levels of sex hormones, mast cell population, ER, and PR expression to near-normal levels. Additionally, molecular docking revealed good binding affinity and best glide scores. These findings suggest that nano encapsulation of CAP@CS-NP 4mg/kg b.wt. administration can regulate hormonal expression to treat hormone receptor-positive mammary carcinoma","PeriodicalId":9156,"journal":{"name":"Bioscience Biotechnology Research Communications","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioscience Biotechnology Research Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21786/bbrc/15.1.39","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The clinical use of capsaicin has been confined due to its low-grade solubility and frail bioavailability. So, we examined the impact of capsaicin encapsulated chitosan nanoparticles (CAP@CS-NP) on chemically induced hormone receptor-positive mammary carcinoma. The mammary tumor was induced by a single dose of 7,12-Dimethylbenz(a)anthracene (DMBA) 25mg/kg b.wt. injected subcutaneously near the mammary gland. After 7 weeks, CAP@CS-NP 4mg/kg b.wt. was administered orally to tumor-bearing rats. Furthermore, sex hormones levels, ER and PR expression, mast cell population, and molecular docking studies were carried out. Tumor-bearing rats flashed significantly hoisted levels of sex hormones, mast cell population, ER, and PR expression. Administration of CAP@CS-NP 4mg/kg b.wt. restored the levels of sex hormones, mast cell population, ER, and PR expression to near-normal levels. Additionally, molecular docking revealed good binding affinity and best glide scores. These findings suggest that nano encapsulation of CAP@CS-NP 4mg/kg b.wt. administration can regulate hormonal expression to treat hormone receptor-positive mammary carcinoma