Acute nephrotoxicity an unusual side effect or adverse toxicity of Captagon

Abstract

Initial complete blood count (CBC) showed hemoglobin 11grams/ dL, total leukocyte count of 9×109/L and platelet count of 460000/ μL. No schistocytes were found on peripheral blood smear. A blood chemistry panel showed urea nitrogen 27mg/dL (8‒21mg/ dL), creatinine 1.1mg/dL (0.8‒1.3mg/dL), sodium 136mmol/L (135‒145mmol/L), potassium 4.2mmol/L (3.5‒5mmol/L), calcium 8.1mg/dL (8.5‒10.2mg/dL), glucose 93mg/ dL (65‒110mg/dL), LDH 240 U/L (120–220U/L), albumin 3.0g/dL (3.5‒5.0g/dL), and total protein 3.2g/dL (5.0–9.0g/dL), HCO3 20mEq/L (22–29mEq/L). Liver function test was normal. Urinalysis revealed protein (+), with increased red blood cells, no eosinophiluria. Serologic test results for anti‒nuclear antibody, anti‒double‒stranded DNA antibody, rheumatoid factor, cryoglobulinemia, hepatitis B and C, and ANCA were negative. Serum C3 and C4 levels were normal.