Investigation of the Effect of Loratadine and Calcium Ions on Oxidoreductase Activity of Catalase Enzyme

Q4 Pharmacology, Toxicology and Pharmaceutics

Current Enzyme Inhibition Pub Date : 2020-08-17 DOI:10.2174/1573408016999200817173859

E. Hasković, S. Herenda, Zehra Halilović, S. Unčanin, Denis Hasković, Ena Deljkić

引用次数: 0

Abstract

The Spectrophotometric method is one of the most suitable analytical techniques for testing the activity of enzymes under the influence of various factors. The effect of H1-antihistamines of loratadine and calcium ions on enzyme catalase under in vitro conditions was investigated in this paper. It has been shown that loratadine is a partial inhibitor of catalase, but this effect is diminished in the presence of calcium ions. Calcium as well as other cations are important for many biological and cellular functions. The kidneys play a central role in the homeostasis of these ions. The activity of the catalase enzyme under the given conditions, the type of inhibition, and the kinetic parameters of the enzyme reaction were determined. We concluded that loratadine is a partially competitive inhibitor.

查看原文本刊更多论文

氯雷他定和钙离子对过氧化氢酶氧化还原酶活性影响的研究

分光光度法是测定受多种因素影响的酶的活性的最合适的分析技术之一。本文在体外条件下研究了氯雷他定和钙离子对过氧化氢酶的影响。氯雷他定是过氧化氢酶的部分抑制剂，但这种作用在钙离子存在下减弱。钙和其他阳离子对许多生物和细胞功能都很重要。肾脏在这些器官的体内平衡中起着核心作用。测定了在给定条件下过氧化氢酶的活性、抑制类型和酶反应的动力学参数。我们得出结论，氯雷他定是一种部分竞争性抑制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Enzyme Inhibition Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.