Tumor Reduction Potentials of Vernonia Cinerea Sesquiterpenes by Induction of Ferroptosis

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2023-05-25 DOI:10.1080/10496475.2023.2217491

Jimsy Johnson, L. Varghese

引用次数: 1

Abstract

ABSTRACT The anti lymphoma potentials of Vernonia cinerea were evaluated. In a short-term in vitro study, ethyl acetate extract (VCEA) was found to be cytotoxic to DLA cells with an LC50 of 61.24 μg mL−1. GC-MS analysis of VCEA revealed presence of several volatile molecules including nerolidol. Molecular docking study using nerolidol with Ferroportin-1 predicted strong binding affinity, indicating ferroptosis induction which was later confirmed by in vitro assays. VCEA also demonstrated strong reduction in the proliferation of YAC-1, another lymphoma cell line with G2/M arrest leading to apoptosis. The tumor reduction potentials of VCEA was further confirmed using the DLA-induced solid tumor model in mice.

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斑蝥二萜类化合物诱导脱铁减瘤作用的研究

摘要:研究了水蛭草的抗淋巴瘤活性。在短期体外实验中，发现乙酸乙酯提取物(VCEA)对DLA细胞具有细胞毒性，LC50为61.24 μg mL−1。GC-MS分析显示，VCEA中存在几种挥发性分子，包括神经樟醇。神经树醇与铁转运蛋白-1的分子对接研究预测了强的结合亲和力，表明铁下垂诱导，随后通过体外实验证实。VCEA还显示出对YAC-1(另一种G2/M阻滞导致细胞凋亡的淋巴瘤细胞系)增殖的强烈抑制。通过dla诱导的小鼠实体瘤模型进一步证实了VCEA的抑瘤作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.