Combining radiation with immune checkpoint inhibitors therapy for HCC: From the alteration of the immune microenvironment by radiotherapy

Q1 Health Professions
Kaixiao Zhou , Yabo Jiang , Shuang Feng , Tingya Wang , Lili Wang , Jianping Cao , Yang Jiao
{"title":"Combining radiation with immune checkpoint inhibitors therapy for HCC: From the alteration of the immune microenvironment by radiotherapy","authors":"Kaixiao Zhou ,&nbsp;Yabo Jiang ,&nbsp;Shuang Feng ,&nbsp;Tingya Wang ,&nbsp;Lili Wang ,&nbsp;Jianping Cao ,&nbsp;Yang Jiao","doi":"10.1016/j.radmp.2022.07.005","DOIUrl":null,"url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC), one of the deadliest cancers all over the world, had a limited prognosis in the past. Recently, the remarkable efficacy of immune checkpoint inhibitors (ICIs) therapy has been shown in various solid tumors. What's more, the occurrence of HCC is associated with immune escape and therefore various ICIs have been applied to clinical trials for HCC. However, the special immune environment of the liver creates the complex tumor microenvironment (TME) of HCC, which impairs the overall survival (OS) and overall response rate (OCR) of ICIs as a monotherapy. Lately, various therapies have been used in combination with ICIs therapy to improve its clinical efficacy. Among which, radiotherapy is widely concerned because of its unique immunoreaction. A large number of basic and clinical studies have demonstrated that the combined radiotherapy and ICIs therapy has advantages in improving the OCR and efficacy, as compared with ICIs therapy alone. Herein, this article reviews the studies on the advantages and possible mechanisms of the combination of radiotherapy and ICIs therapy for HCC.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"3 4","pages":"Pages 183-189"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555722000454/pdfft?md5=c70caeb2c6738767da1eca1f6d479b38&pid=1-s2.0-S2666555722000454-main.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiation Medicine and Protection","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666555722000454","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Health Professions","Score":null,"Total":0}
引用次数: 1

Abstract

Hepatocellular carcinoma (HCC), one of the deadliest cancers all over the world, had a limited prognosis in the past. Recently, the remarkable efficacy of immune checkpoint inhibitors (ICIs) therapy has been shown in various solid tumors. What's more, the occurrence of HCC is associated with immune escape and therefore various ICIs have been applied to clinical trials for HCC. However, the special immune environment of the liver creates the complex tumor microenvironment (TME) of HCC, which impairs the overall survival (OS) and overall response rate (OCR) of ICIs as a monotherapy. Lately, various therapies have been used in combination with ICIs therapy to improve its clinical efficacy. Among which, radiotherapy is widely concerned because of its unique immunoreaction. A large number of basic and clinical studies have demonstrated that the combined radiotherapy and ICIs therapy has advantages in improving the OCR and efficacy, as compared with ICIs therapy alone. Herein, this article reviews the studies on the advantages and possible mechanisms of the combination of radiotherapy and ICIs therapy for HCC.

放疗联合免疫检查点抑制剂治疗肝癌:从放疗对免疫微环境的改变看
肝细胞癌(HCC)是世界上最致命的癌症之一,过去预后有限。近年来,免疫检查点抑制剂(ICIs)治疗多种实体瘤的疗效显著。更重要的是,HCC的发生与免疫逃逸有关,因此各种ICIs已被应用于HCC的临床试验。然而,肝脏特殊的免疫环境造成HCC复杂的肿瘤微环境(TME),损害了ICIs作为单药治疗的总生存期(OS)和总缓解率(OCR)。近年来,各种治疗方法与ICIs治疗相结合,以提高其临床疗效。其中,放射治疗因其独特的免疫反应而受到广泛关注。大量的基础和临床研究表明,与单独使用ICIs治疗相比,放疗联合ICIs治疗在提高OCR和疗效方面具有优势。本文就肝细胞癌放疗与ICIs联合治疗的优势及可能机制的研究进展进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Radiation Medicine and Protection
Radiation Medicine and Protection Health Professions-Emergency Medical Services
CiteScore
2.10
自引率
0.00%
发文量
0
审稿时长
103 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信