Therapeutic response and safety of different treatments for cutaneous leishmaniasis in patients treated at a research center in Medellin - Antioquia, Colombia, between 2016 – 2021

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-07-01 DOI:10.4103/1995-7645.380719

Nicolás Rozo Montoya, Juliana Quintero Pulgarín, L. Carvajal

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Abstract

To analyze the therapeutic response and safety of different treatments for cutaneous leishmaniasis, received by patients in the Program for the Study and Control of Tropical Diseases- PECET-Medellín-Colombia. This is a retrospective cross-sectional study of patients attended at PECET Research Center during 2016-2021. Relevant information regarding sociodemographic characteristics, history of leishmaniasis, characterization of current infection, treatment received, follow-up of therapeutic response and safety was collected from the medical records. Data were analyzed with Pearson's Chi-square association tests and Mann-Whitney U test using statistical software. A total of 486 clinical records of patients were analyzed, and 356 received treatment. Eight different therapeutic alternatives (systemic, local and in combination) were analyzed. The therapeutic response of the different alternatives used (except thermotherapy) was higher than 50%. Most frequent adverse events were myalgias, arthralgias and headache, and vesicles for systemic and local treatment, respectively. Safety profile and performance of local therapeutic alternatives and combined schemes for the treatment of uncomplicated cutaneous leishmaniasis are an interesting option for the management of the disease.

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2016年至2021年期间在哥伦比亚麦德林-安蒂奥基亚研究中心治疗的皮肤利什曼病患者不同治疗方法的治疗反应和安全性

分析热带疾病研究和控制项目（PECET Medellín-Colombia）患者对皮肤利什曼病不同治疗方法的治疗效果和安全性。这是一项对2016-2021年PECET研究中心就诊患者的回顾性横断面研究。从医疗记录中收集有关社会人口学特征、利什曼病病史、当前感染特征、接受的治疗、治疗反应的随访和安全性的相关信息。数据采用Pearson卡方关联检验和Mann-Whitney U检验进行统计分析。共分析了486例患者的临床记录，356例接受了治疗。分析了八种不同的治疗方案（全身、局部和联合）。使用的不同替代方案（热疗除外）的治疗效果均高于50%。最常见的不良事件分别是肌痛、关节痛和头痛，以及全身和局部治疗的囊泡。治疗无并发症皮肤利什曼病的局部治疗替代方案和联合方案的安全性和性能是治疗该疾病的一个有趣的选择。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.