Flavor Enhancement in Daily Life of Patients with Olfactory Dysfunction

IF 1 4区医学 Q4 Neuroscience

Chemosensory Perception Pub Date : 2021-07-08 DOI:10.1007/s12078-021-09289-0

Martin Koenighofer, Verena Niebauer, David Tianxiang Liu, Bertold Renner, Gerold Besser, Christian A. Mueller

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引用次数: 1

Abstract

Introduction

Patients with olfactory dysfunction report deterioration of taste due to loss of flavor, leading to less food enjoyment, alterations in dietary behaviors and stress. The aim of this study was to introduce flavor enhancement to investigate its acceptance and possible effects on quality of life.

Methods

In this prospective, controlled, randomized, single-blinded, cross-over pilot study, we recruited 30 olfactory dysfunction patients, of which 16 were hyposmic and 14 anosmic. After single-blinded triangle flavor discrimination test, flavor drops were randomized either in high or low concentration for 14 days and vice versa for another 14 days. Records included a daily diary and the questionnaire of olfactory disorders.

Results

Usage rates were excellent with 82.2% of all days, while drops were mainly used for breakfast (44.6%, p < 0.05). Hyposmics used flavor enhancement on significantly more days (median = 14) compared to anosmics (median = 11, p = 0.0094). QOD improved in 12 patients to a meaningful extent.

Conclusions

In this pilot study, we show that flavor enhancement is feasible accompanied by high compliance and acceptance in olfactory dysfunction patients. Flavor drops were used regardless of low or high concentrations with no adverse events noted.

Implications

Our findings give rise to further studies illuminating the possible advantages of flavor enhancement in patients with olfactory disorders.

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嗅觉功能障碍患者日常生活中的风味增强

嗅觉功能障碍患者报告由于风味丧失而导致味觉恶化，导致食物享受减少，饮食行为改变和压力。本研究的目的是介绍风味增强，探讨其接受程度和可能对生活质量的影响。方法在这项前瞻性、对照、随机、单盲、交叉的先导研究中，我们招募了30例嗅觉功能障碍患者，其中16例嗅觉减退，14例嗅觉缺失。单盲三角风味判别试验结束后，将风味滴液按高浓度或低浓度随机分配14 d，反之则随机分配14 d。记录包括每日日记和嗅觉障碍问卷。结果全日消食率为82.2%，以早餐消食为主(44.6%，p < 0.05)。与嗅觉缺失患者(中位数= 11,p = 0.0094)相比，嗅觉缺失患者使用风味增强的天数明显更多(中位数= 14)。12例患者QOD有明显改善。结论在本初步研究中，我们证明了嗅觉功能障碍患者的风味增强是可行的，并且具有较高的依从性和接受度。无论浓度高低，都使用风味滴剂，没有注意到不良事件。我们的研究结果引发了进一步的研究，阐明了嗅觉障碍患者的风味增强可能的优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemosensory Perception 农林科学-神经科学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： Coverage in Chemosensory Perception includes animal work with implications for human phenomena and explores the following areas: Identification of chemicals producing sensory response; Identification of sensory response associated with chemicals; Human in vivo response to chemical stimuli; Human in vitro response to chemical stimuli; Neuroimaging of chemosensory function; Neurological processing of chemoreception; Chemoreception mechanisms; Psychophysics of chemoperception; Trigeminal function; Multisensory perception; Contextual effect on chemoperception; Behavioral response to chemical stimuli; Physiological factors affecting and contributing to chemoperception; Flavor and hedonics; Memory and chemoperception.