Ashton Curry-Hyde, Bei Jun Chen, J. D. Mills, M. Janitz
{"title":"Microexons: novel regulators of the transcriptome","authors":"Ashton Curry-Hyde, Bei Jun Chen, J. D. Mills, M. Janitz","doi":"10.1080/23324015.2018.1491940","DOIUrl":null,"url":null,"abstract":"Abstract Alternative splicing of RNA is a fundamental post-transcriptional regulatory process that leads to a vast diversity of proteins being translated from a relatively small number of genomic loci. Microexons, a set of very small protein-coding sequences of 1-17 amino acids, have only recently been recognised as an important part of pre-mRNA processing. Recent studies have revealed that microexons can play important roles in various cellular functions, protein-protein interactions and have also been associated with various neurological diseases. This review provides an update on research covering the functional impact of microexons on the biology of a cell and disease, and the mechanisms by which their splicing is regulated. Finally, the current bioinformatics methods for detecting microexons are discussed.","PeriodicalId":91543,"journal":{"name":"Journal of human transcriptome","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23324015.2018.1491940","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of human transcriptome","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/23324015.2018.1491940","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
Abstract Alternative splicing of RNA is a fundamental post-transcriptional regulatory process that leads to a vast diversity of proteins being translated from a relatively small number of genomic loci. Microexons, a set of very small protein-coding sequences of 1-17 amino acids, have only recently been recognised as an important part of pre-mRNA processing. Recent studies have revealed that microexons can play important roles in various cellular functions, protein-protein interactions and have also been associated with various neurological diseases. This review provides an update on research covering the functional impact of microexons on the biology of a cell and disease, and the mechanisms by which their splicing is regulated. Finally, the current bioinformatics methods for detecting microexons are discussed.