Xin Jiang , Qiang Sebastian Shi , Cheng-Yu Wu , Lu Xu , Hongji Yang , MedhatAskar
{"title":"Investigative and laboratory assays for allogeneic rejection – A clinical perspective","authors":"Xin Jiang , Qiang Sebastian Shi , Cheng-Yu Wu , Lu Xu , Hongji Yang , MedhatAskar","doi":"10.1016/j.tpr.2023.100133","DOIUrl":null,"url":null,"abstract":"<div><p>How to translate basic research on surveillances for post organs transplantation facilitates the development of new laboratory tools for clinical application. Here, we provide the pertinent guide on how to analyze laboratory data in order to help clinicians to accurately determine the status of allograft in the recipient. We begin by discussing the molecular and cellular events that lead to allograft rejection across innate and adaptive immune responses. We focus on the allograft injury events that occur around the time of transplantation as well as molecular activities that ensue long before observable microscopic abnormalities are evident in biopsied samples. Then, we introduce and comment on new technologies involved in rejection detection from a practical point of view. This review outlines the current diagnostic development, describes unmet needs and challenges, and proposes new approaches for future directions.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transplantation Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451959623000082","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 1
Abstract
How to translate basic research on surveillances for post organs transplantation facilitates the development of new laboratory tools for clinical application. Here, we provide the pertinent guide on how to analyze laboratory data in order to help clinicians to accurately determine the status of allograft in the recipient. We begin by discussing the molecular and cellular events that lead to allograft rejection across innate and adaptive immune responses. We focus on the allograft injury events that occur around the time of transplantation as well as molecular activities that ensue long before observable microscopic abnormalities are evident in biopsied samples. Then, we introduce and comment on new technologies involved in rejection detection from a practical point of view. This review outlines the current diagnostic development, describes unmet needs and challenges, and proposes new approaches for future directions.
期刊介绍：
To provide to national and regional audiences experiences unique to them or confirming of broader concepts originating in large controlled trials. All aspects of organ, tissue and cell transplantation clinically and experimentally. Transplantation Reports will provide in-depth representation of emerging preclinical, impactful and clinical experiences. -Original basic or clinical science articles that represent initial limited experiences as preliminary reports. -Clinical trials of therapies previously well documented in large trials but now tested in limited, special, ethnic or clinically unique patient populations. -Case studies that confirm prior reports but have occurred in patients displaying unique clinical characteristics such as ethnicities or rarely associated co-morbidities. Transplantation Reports offers these benefits: -Fast and fair peer review -Rapid, article-based publication -Unrivalled visibility and exposure for your research -Immediate, free and permanent access to your paper on Science Direct -Immediately citable using the article DOI
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