Immunological Approach of Personalized Treatment for Recurrent Implantation Failure Patients Undergoing IVF

Abstract

Genes related to immune and inflammatory response initiate the process of endometrial receptivity. It stimulates the cascade of biological functions like cell differentiation, vasculogenesis, and expression of cell adhesion markers at the endometrium to which the invading embryo attaches. Dysregulation in immunological response results in impairment in endometrial receptivity leading to implantation failure. In our study, we have evaluated the expression of genes involved in immune and inflammatory response in recurrent implantation failure patients and designed the personalized immunological treatment and cycle in which the embryo transfer to be recommended, based on the gene expression results. We achieved success in two out of four cases having normal expression and down-regulation of immune response respectively, in natural cycle. However, the approach is required to be implemented in larger cohort of implantation failure patients to confirm its efficiency.