Sarcomatoid malignant pleural mesothelioma associated with anti-Ma2-related paraneoplastic neurological syndrome: A case report

IF 0.2 Q4 ONCOLOGY

Current problems in cancer. Case reports Pub Date : 2023-09-01 DOI:10.1016/j.cpccr.2023.100244

Akio Tada , Kozo Kuribayashi , Kazuhiro Kitajima , Akifumi Nakamura , Michiko Yuki , Shingo Kanemura , Eisuke Shibata , Yoshiki Negi , Hirotoshi Ishigaki , Yasuhiro Nakajima , Ryo Takahashi , Takashi Yokoi , Toshiyuki Minami , Takashi Kijima

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引用次数: 0

Abstract

Paraneoplastic neurological syndrome (PNS) is rarely associated with malignant pleural mesothelioma (MPM). We report the first case of sarcomatoid mesothelioma in a 63-year-old female diagnosed with cerebellar degeneration in January 2018. Systemic examination showed right pleura thickening. The pleural biopsy of the mass revealed a sarcomatoid MPM cT3N0M0. In February 2018, anti-Ma2 antibody positivity indicated PNS complicated with MPM. First, cisplatin (75 mg/m²) + pemetrexed (500 mg/m²) chemotherapy was given. For PNS, steroid pulse therapy and high-dose immunoglobulin therapy were administered. MPM may cause anti-Ma2 antibody-related PNS. Early diagnosis and starting anticancer treatment and immunotherapy are critical.

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肉瘤样恶性胸膜间皮瘤伴抗ma2相关副肿瘤神经综合征1例报告

副肿瘤神经系统综合征(PNS)很少与恶性胸膜间皮瘤(MPM)相关。我们报告了2018年1月诊断为小脑变性的63岁女性的第一例肉瘤样间皮瘤。全身检查显示右侧胸膜增厚。肿块的胸膜活检显示肉瘤样MPM cT3N0M0。2018年2月，抗ma2抗体阳性提示PNS合并MPM。首先给予顺铂(75 mg/m2) +培美曲塞(500 mg/m2)化疗。对于PNS，给予类固醇脉冲治疗和大剂量免疫球蛋白治疗。MPM可能引起抗ma2抗体相关的PNS。早期诊断和开始抗癌治疗和免疫治疗是至关重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current problems in cancer. Case reports Oncology

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

96 days