Synthesis and antitubercular activity of new N-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]-(nitroheteroaryl)carboxamides

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2019-01-01 DOI:10.1515/hc-2019-0007

R. Martínez, Gladys J. Nieves Zamudio, Gustavo Pretelín-Castillo, Rubén O. Torres-Ochoa, J. Medina‐Franco, Clara I. Espitia Pinzón, M. Miranda, Eugenio Hernández, B. Alanís-Garza

引用次数: 11

Abstract

Abstract Nitro-substituted heteroaromatic carboxamides 1a-e were synthesized and tested against three Mycobacterium tuberculosis cell lines. The activities can be explained in terms of the distribution of the electronic density across the nitro-substituted heteroaromatic ring attached to the amide group. 1,3,5-Oxadiazole derivatives 1c-e are candidates for the development of novel antitubercular agents. Ongoing studies are focused on exploring the mechanism by which these compounds inhibit M. tuberculosis cell growth.

查看原文本刊更多论文

新型N-[5-(4-氯苯基)-1,3,4-恶二唑-2-基]-(硝基杂芳基)羧胺的合成及抗结核活性

摘要合成了硝基取代杂芳酰胺1a-e，并对三种结核分枝杆菌细胞株进行了检测。活性可以用连接在酰胺基上的硝基取代的杂芳环上的电子密度分布来解释。1,3,5-恶二唑衍生物1c-e是开发新型抗结核药物的候选者。正在进行的研究集中于探索这些化合物抑制结核分枝杆菌细胞生长的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.