Current prospects on nano liquid chromatography coupled to electron ionization mass spectrometry (nanoLC-EI-MS)

IF 1 4区化学 Q4 BIOCHEMICAL RESEARCH METHODS

Journal of Liquid Chromatography & Related Technologies Pub Date : 2021-12-14 DOI:10.1080/10826076.2022.2110114

D. A. Vargas Medina, Natalia Gabrielly Pereira dos Santos, E. Maciel, F. Lanças

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引用次数: 2

Abstract

Abstract NanoLC consolidates as powerful analytical technology liable to provide improved chromatographic performance and superior detection capabilities. Significant instrumental advances have been accomplished in the last 20 years to make nanoLC instruments more robust, accurate, and amenable for routine analysis. Similarly, new stationary phases and nanoLC formats provide new opportunities for separations at the miniaturized scale. Besides, nanoLC makes the hyphenation with EI-MS feasible, and a series of interfaces and interesting applications have been reported in the last years. Ei-MS offers unparallel identification capabilities, and its coupling with nanoLC has the potential to revolutionize the Performance of LC-MS untargeted studies. This manuscript makes a historical journey through the development of the nanoLC and its hyphenation with the EI-MS, exploring the more outstanding advances in that technology, discussing its scope, and identifying its limitations. We intend to give the reader a current overview of the state of the art of nanoLC and point out perspectives and future lines of advancement and improvement for new research in this area. Graphical Abstract

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纳米液相色谱-电子电离质谱联用技术的发展前景

NanoLC是一种强大的分析技术，可提供改进的色谱性能和优越的检测能力。在过去的20年里，重大的仪器进步已经完成，使纳米olc仪器更加坚固，准确，并适用于常规分析。同样，新的固定相和纳米olc格式为小型化的分离提供了新的机会。此外，纳米olc使得与EI-MS的连字符化成为可能，并且在过去的几年里已经报道了一系列的接口和有趣的应用。Ei-MS提供了无与伦比的鉴定能力，它与纳米olc的耦合有可能彻底改变LC-MS非靶向研究的性能。该手稿通过纳米olc的发展及其与EI-MS的连字符，探索该技术的更突出的进步，讨论其范围，并确定其局限性的历史之旅。我们打算给读者一个纳米有机碳技术现状的概述，并指出在这一领域的新研究的前景和未来的发展和改进。图形抽象

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来源期刊

Journal of Liquid Chromatography & Related Technologies 化学-分析化学

CiteScore

2.80

自引率

0.00%

发文量

审稿时长

4.9 months

期刊介绍： The Journal of Liquid Chromatography & Related Technologies is an internationally acclaimed forum for fast publication of critical, peer reviewed manuscripts dealing with analytical, preparative and process scale liquid chromatography and all of its related technologies, including TLC, capillary electrophoresis, capillary electrochromatography, supercritical fluid chromatography and extraction, field-flow technologies, affinity, and much more. New separation methodologies are added when they are developed. Papers dealing with research and development results, as well as critical reviews of important technologies, are published in the Journal.