Disease severity and renal function among sickle cell anaemia patients in a tertiary hospital, South-south, Nigeria: a cross sectional study.

IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Ajeigbe K Abiodun, Adejumo Oluseyi, Owojuyigbe Temilola, Ayinbuomwan Ekiye, Okesina A Bashiru
{"title":"Disease severity and renal function among sickle cell anaemia patients in a tertiary hospital, South-south, Nigeria: a cross sectional study.","authors":"Ajeigbe K Abiodun, Adejumo Oluseyi, Owojuyigbe Temilola, Ayinbuomwan Ekiye, Okesina A Bashiru","doi":"10.4314/mmj.v35i1.3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Renal disease is a recognized complication of sickle cell anaemia (SCA), especially from the third decade of life and is linked to disease severity. This study assessed the association between disease severity and renal function among SCA patients using routine and newer markers of renal function.</p><p><strong>Methods: </strong>This cross-sectional study recruited 85 SCA patients. Disease severity was assessed using modified Adegoke criteria which include the frequency of transfusion, painful crises, packed cell volume, and history of complications such as hypertension and chronic leg ulcers. Renal function was assessed using urea, creatinine, and beta-2-microglobulin (β2-M). Association was determined between renal function and disease severity using Pearson's correlation. P-value < 0.05 was taken as significant.</p><p><strong>Results: </strong>The mean age of participants was 27.2 ± 7.6 years with 41(48.2%) males and 44 (51.8%) females. The mean packed cell volume, serum creatinine, serum urea, and β2-M were 24.0± 4.1%,17.6±7.5 mg/dL, 0.7±0.3mg/dL, 3.4±1.2mg/l respectively. A majority (54.1%) of them had a mild disease while 35.3% and 10.6% had moderate and severe diseases, respectively. Forty of the SCA patients had urine specific gravity below 1.010. The mean values of systolic blood pressure (p=0.001) diastolic blood pressure (p=0.001), serum creatinine (p=0.028) and β2M (p=0.019) significantly increased with disease severity. There was a significant positive correlation between SCA disease severity and serum urea (r=0.229; p=0.035), and serum β2-microglobulin (r=0.270; p=0.012).</p><p><strong>Conclusion: </strong>Sickle cell anaemia severity is associated with a decline in renal function using both traditional and novel renal markers. Serum β2-M may serve as a useful marker of renal function and disease severity in SCA.</p>","PeriodicalId":18185,"journal":{"name":"Malawi Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645894/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Malawi Medical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4314/mmj.v35i1.3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Renal disease is a recognized complication of sickle cell anaemia (SCA), especially from the third decade of life and is linked to disease severity. This study assessed the association between disease severity and renal function among SCA patients using routine and newer markers of renal function.

Methods: This cross-sectional study recruited 85 SCA patients. Disease severity was assessed using modified Adegoke criteria which include the frequency of transfusion, painful crises, packed cell volume, and history of complications such as hypertension and chronic leg ulcers. Renal function was assessed using urea, creatinine, and beta-2-microglobulin (β2-M). Association was determined between renal function and disease severity using Pearson's correlation. P-value < 0.05 was taken as significant.

Results: The mean age of participants was 27.2 ± 7.6 years with 41(48.2%) males and 44 (51.8%) females. The mean packed cell volume, serum creatinine, serum urea, and β2-M were 24.0± 4.1%,17.6±7.5 mg/dL, 0.7±0.3mg/dL, 3.4±1.2mg/l respectively. A majority (54.1%) of them had a mild disease while 35.3% and 10.6% had moderate and severe diseases, respectively. Forty of the SCA patients had urine specific gravity below 1.010. The mean values of systolic blood pressure (p=0.001) diastolic blood pressure (p=0.001), serum creatinine (p=0.028) and β2M (p=0.019) significantly increased with disease severity. There was a significant positive correlation between SCA disease severity and serum urea (r=0.229; p=0.035), and serum β2-microglobulin (r=0.270; p=0.012).

Conclusion: Sickle cell anaemia severity is associated with a decline in renal function using both traditional and novel renal markers. Serum β2-M may serve as a useful marker of renal function and disease severity in SCA.

尼日利亚南南三级医院镰状细胞贫血患者的疾病严重程度和肾功能:一项横断面研究
背景肾脏疾病是公认的镰状细胞贫血(SCA)并发症,尤其是在生命的第三个十年,与疾病的严重程度有关。本研究使用常规和更新的肾功能标志物评估SCA患者的疾病严重程度与肾功能之间的关系。方法本横断面研究招募了85名SCA患者。使用改良的Adegoke标准评估疾病的严重程度,该标准包括输血频率、疼痛危象、细胞堆积量以及高血压和慢性腿部溃疡等并发症的病史。使用尿素、肌酸酐和β-2-微球蛋白(β2-M)评估肾功能。使用Pearson相关性确定肾功能和疾病严重程度之间的相关性。P值<0.05为显著性。结果参与者的平均年龄为27.2±7.6岁,其中男性41人(48.2%),女性44人(51.8%)。平均堆积细胞体积、血清肌酐、血清尿素和β2-M分别为24.0±4.1%、17.6±7.5mg/dL、0.7±0.3mg/dL和3.4±1.2mg/l。其中大多数(54.1%)患有轻度疾病,35.3%和10.6%分别患有中度和重度疾病。40名SCA患者的尿液比重低于1.010。收缩压(p=0.001)、舒张压(p=0.001)、血清肌酐(p=0.028)和β2M(p=0.019)的平均值随疾病严重程度的增加而显著增加。SCA疾病的严重程度与血清尿素(r=0.229;p=0.035)和血清β2-微球蛋白(r=0.270;p=0.012)呈正相关。血清β2-M可能是SCA肾功能和疾病严重程度的有用标志物
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Malawi Medical Journal
Malawi Medical Journal Medicine-General Medicine
CiteScore
1.50
自引率
0.00%
发文量
27
审稿时长
>12 weeks
期刊介绍: Driven and guided by the priorities articulated in the Malawi National Health Research Agenda, the Malawi Medical Journal publishes original research, short reports, case reports, viewpoints, insightful editorials and commentaries that are of high quality, informative and applicable to the Malawian and sub-Saharan Africa regions. Our particular interest is to publish evidence-based research that impacts and informs national health policies and medical practice in Malawi and the broader region. Topics covered in the journal include, but are not limited to: - Communicable diseases (HIV and AIDS, Malaria, TB, etc.) - Non-communicable diseases (Cardiovascular diseases, cancer, diabetes, etc.) - Sexual and Reproductive Health (Adolescent health, education, pregnancy and abortion, STDs and HIV and AIDS, etc.) - Mental health - Environmental health - Nutrition - Health systems and health policy (Leadership, ethics, and governance) - Community systems strengthening research - Injury, trauma, and surgical disorders
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信