Replacing dietary sodium selenite with biogenic selenium nanoparticles improves the growth performance and gut health of early-weaned piglets

IF 6.3
Lei Qiao , Xina Dou , Xiaofan Song , Jiajing Chang , Xiaonan Zeng , Lixu Zhu , Hongbo Yi , Chunlan Xu
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引用次数: 1

Abstract

Selenium nanoparticles (SeNPs) are proposed as a safer and more effective selenium delivery system than sodium selenite (Na2SeO3). Here, we investigated the effects of replacing dietary Na2SeO3 with SeNPs synthesized by Lactobacillus casei ATCC 393 on the growth performance and gut health of early-weaned piglets. Seventy-two piglets (Duroc × Landrace × Large Yorkshire) weaned at 21 d of age were divided into the control group (basal diet containing 0.3 mg Se/kg from Na2SeO3) and SeNPs group (basal diet containing 0.3 mg Se/kg from SeNPs) during a 14-d feeding period. The results revealed that SeNPs supplementation increased the average daily gain (P = 0.022) and average daily feed intake (P = 0.033), reduced (P = 0.056) the diarrhea incidence, and improved (P = 0.013) the feed conversion ratio compared with Na2SeO3. Additionally, SeNPs increased jejunal microvilli height (P = 0.006) and alleviated the intestinal barrier dysfunction by upregulating (P < 0.05) the expression levels of mucin 2 and tight junction proteins, increasing (P < 0.05) Se availability, and maintaining mitochondrial structure and function, thereby improving antioxidant capacity and immunity. Furthermore, metabolomics showed that SeNPs can regulate lipid metabolism and participate in the synthesis, secretion and action of parathyroid hormone, proximal tubule bicarbonate reclamation and tricarboxylic acid cycle. Moreover, SeNPs increased (P < 0.05) the abundance of Holdemanella and the levels of acetate and propionate. Correlation analysis suggested that Holdemanella was closely associated with the regulatory effects of SeNPs on early-weaned piglets through participating in lipid metabolism. Overall, replacing dietary Na2SeO3 with biogenic SeNPs could be a potential nutritional intervention strategy to prevent early-weaning syndrome in piglets.

用生物源性纳米硒替代饲粮亚硒酸钠可改善早期断奶仔猪的生长性能和肠道健康
硒纳米粒子(SeNPs)是一种比亚硒酸钠(Na2SeO3)更安全、更有效的硒递送系统。本试验旨在研究用干酪乳杆菌ATCC 393合成的SeNPs替代饲粮Na2SeO3对早期断奶仔猪生长性能和肠道健康的影响。选用21日龄断奶的杜×长×大仔猪72头,分为对照组(基础饲粮中添加0.3 mg硒/kg Na2SeO3)和SeNPs组(基础饲粮中添加0.3 mg硒/kg SeNPs),饲喂14 d。结果表明,与Na2SeO3相比,添加SeNPs提高了平均日增重(P = 0.022)和平均日采食量(P = 0.033),降低了腹泻发生率(P = 0.056),提高了饲料系数(P = 0.013)。此外,SeNPs增加了空肠微绒毛高度(P = 0.006),并通过上调(P <0.05),黏液蛋白2和紧密连接蛋白的表达水平升高(P <0.05)硒利用率,维持线粒体结构和功能,从而提高抗氧化能力和免疫力。代谢组学研究表明,SeNPs可以调节脂质代谢,参与甲状旁腺激素的合成、分泌和作用、近端小管碳酸氢盐回收和三羧酸循环。此外,SeNPs增加(P <0.05) Holdemanella丰度和乙酸、丙酸水平。相关分析表明,Holdemanella通过参与脂质代谢,与SeNPs对早期断奶仔猪的调节作用密切相关。总之,用生物源性SeNPs替代饲粮Na2SeO3可能是预防仔猪早期断奶综合征的潜在营养干预策略。
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来源期刊
Animal Nutrition
Animal Nutrition Animal Science and Zoology
CiteScore
9.70
自引率
0.00%
发文量
542
审稿时长
65 days
期刊介绍: Animal Nutrition encompasses the full gamut of animal nutritional sciences and reviews including, but not limited to, fundamental aspects of animal nutrition such as nutritional requirements, metabolic studies, body composition, energetics, immunology, neuroscience, microbiology, genetics and molecular and cell biology related to primarily to the nutrition of farm animals and aquatic species. More applied aspects of animal nutrition, such as the evaluation of novel ingredients, feed additives and feed safety will also be considered but it is expected that such studies will have a strong nutritional focus. Animal Nutrition is indexed in SCIE, PubMed Central, Scopus, DOAJ, etc.
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