The risk factors for radial artery and saphenous vein graft occlusion are different

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-06-02 DOI:10.1080/14017431.2022.2079716

Ramez Bahar, S. E. Hermansen, Øystein Dahl-Eriksen, R. Busund, P. Dahl, A. Iqbal, J. Mannsverk, T. Myrmel, T. Steigen, T. Trovik, D. Sørlie, K. Bartnes

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Abstract

Abstract Objectives. To determine risk factors for radial artery and saphenous vein graft occlusion during long-term follow-up after coronary artery bypass grafting (CABG). Methods: From a cohort of 119 patients who had received a radial artery graft, 76 – of whom 55 also had at least one saphenous vein graft – underwent a preplanned direct angiography and anthropometric, biochemical, and endothelial function assessment 7.6–12.1 (mean 8.9) years after CABG. Comorbidity, medication, and smoking habits were also recorded. The association between these parameters and conduit longevity was analyzed in univariable and multivariable logistic regression models. Results: Radial artery graft occlusions were associated with higher plasma levels of high-sensitive C-reactive protein and patency was best among patients with pharmacologically treated hypertension. The sole independent risk factor identified for saphenous vein graft occlusion was tobacco smoking 8–12 years postoperatively. Conclusion: Our data support the contention that the pathogenesis of radial artery graft failure is distinct from vein graft disease and is related to hypertension status and systemic inflammation. These risk factors are potential targets for preventive measures. Accordingly, the study supports the eventual design of personalized secondary prevention regimens. Clinical registration number: ISRCTN23118170

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桡动脉和隐静脉移植物闭塞的危险因素不同

抽象目标。确定冠状动脉搭桥术（CABG）后长期随访中桡动脉和隐静脉移植物闭塞的危险因素。方法：从119名接受过桡动脉移植的患者队列中，76名患者（其中55名患者至少接受了一次隐静脉移植）在冠状动脉旁路移植术后7.6-12.1年（平均8.9年）接受了预先计划的直接血管造影术和人体测量、生化和内皮功能评估。还记录了合并症、药物和吸烟习惯。在单变量和多变量逻辑回归模型中分析了这些参数与导管寿命之间的关系。结果：桡动脉移植物闭塞与血浆高敏C反应蛋白水平升高有关，在药物治疗的高血压患者中，通畅性最好。隐静脉移植物闭塞的唯一独立危险因素是吸烟8-12 术后数年。结论：我们的数据支持这样一种论点，即桡动脉移植物衰竭的发病机制不同于静脉移植物疾病，并与高血压状态和全身炎症有关。这些风险因素是预防措施的潜在目标。因此，该研究支持最终设计个性化的二级预防方案。临床注册号：ISRCTN23118170

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.