AUTISM SPECTRUM DISORDER AND POSTNATAL FACTORS: A CASE-CONTROL STUDY IN BRAZIL

IF 1.4 Q3 PEDIATRICS

Revista Paulista De Pediatria Pub Date : 2019-07-18 DOI:10.1590/1984-0462/;2019;37;4;00006

Fernanda Alves Maia, Liliane Marta Mendes Oliveira, Maria Tereza Carvalho Almeida, M. Alves, Vanessa Souza de Araújo Saeger, V. Silva, Victória Spínola Duarte de Oliveira, H. Martelli Júnior, M. Brito, M. Silveira

{"title":"AUTISM SPECTRUM DISORDER AND POSTNATAL FACTORS: A CASE-CONTROL STUDY IN BRAZIL","authors":"Fernanda Alves Maia, Liliane Marta Mendes Oliveira, Maria Tereza Carvalho Almeida, M. Alves, Vanessa Souza de Araújo Saeger, V. Silva, Victória Spínola Duarte de Oliveira, H. Martelli Júnior, M. Brito, M. Silveira","doi":"10.1590/1984-0462/;2019;37;4;00006","DOIUrl":null,"url":null,"abstract":"ABSTRACT Objective: To estimate the magnitude of the association between Autism Spectrum Disorder (ASD) and postnatal factors in a Brazilian population. Methods: A case-control study was performed with 253 individuals diagnosed with ASD and 886 individuals without signs of the disorder. A semi-structured questionnaire and the multiple logistic regression model were adopted in the data analysis. To estimate the magnitude of associations, the crude and adjusted Odds Ratio (OR) was used. Results: An association with the following factors was found: having been born with congenital malformation (OR 4.24; confidence interval of 95% - 95%CI 1.92-9.34), neonatal jaundice (OR 1.43; 95%CI 1.01-2.02), absence of crying at birth and seizure episode in childhood (OR 5.75; 95%CI 3.37-9.81). The magnitude of the association was higher in the children/adolescents who had two or more postnatal complications (OR 6.39; 95%CI 4.10-10.00). Conclusions: The findings of the present study suggest that malformation, neonatal jaundice, absence of crying at birth and seizure episodes in childhood are important factors to be considered when studying the etiology of ASD.","PeriodicalId":21311,"journal":{"name":"Revista Paulista De Pediatria","volume":"37 1","pages":"398 - 405"},"PeriodicalIF":1.4000,"publicationDate":"2019-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/1984-0462/;2019;37;4;00006","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Paulista De Pediatria","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/1984-0462/;2019;37;4;00006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 9

Abstract

ABSTRACT Objective: To estimate the magnitude of the association between Autism Spectrum Disorder (ASD) and postnatal factors in a Brazilian population. Methods: A case-control study was performed with 253 individuals diagnosed with ASD and 886 individuals without signs of the disorder. A semi-structured questionnaire and the multiple logistic regression model were adopted in the data analysis. To estimate the magnitude of associations, the crude and adjusted Odds Ratio (OR) was used. Results: An association with the following factors was found: having been born with congenital malformation (OR 4.24; confidence interval of 95% - 95%CI 1.92-9.34), neonatal jaundice (OR 1.43; 95%CI 1.01-2.02), absence of crying at birth and seizure episode in childhood (OR 5.75; 95%CI 3.37-9.81). The magnitude of the association was higher in the children/adolescents who had two or more postnatal complications (OR 6.39; 95%CI 4.10-10.00). Conclusions: The findings of the present study suggest that malformation, neonatal jaundice, absence of crying at birth and seizure episodes in childhood are important factors to be considered when studying the etiology of ASD.

查看原文本刊更多论文

自闭症谱系障碍和产后因素:巴西的一项病例对照研究

目的:评估巴西人群中自闭症谱系障碍(ASD)与出生后因素之间的关联程度。方法:对253名诊断为ASD的个体和886名无症状的个体进行病例对照研究。数据分析采用半结构化问卷和多元逻辑回归模型。为了估计关联的程度，使用了粗糙和调整后的优势比(OR)。结果:发现与以下因素相关:出生时患有先天性畸形(OR 4.24;可信区间为95% - 95% ci 1.92-9.34)，新生儿黄疸(OR 1.43;95%CI 1.01-2.02)，出生时无哭闹和儿童期癫痫发作(OR 5.75;95%可信区间3.37 - -9.81)。有两种或两种以上产后并发症的儿童/青少年的相关性更高(or 6.39;95%可信区间4.10 - -10.00)。结论:本研究结果提示，畸形、新生儿黄疸、出生时无哭声和儿童期癫痫发作是研究ASD病因时需要考虑的重要因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Revista Paulista De Pediatria Medicine-Pediatrics, Perinatology and Child Health

CiteScore

2.30

自引率

0.00%

发文量

100

审稿时长

11 weeks

期刊介绍： The Revista Paulista de Pediatria publishes original contributions, case reports and review of clinical research with methodological approach in the areas of health and disease of neonates, infants, children and adolescents. The objective is to disseminate research with methodological quality on issues that comprise the health of children and adolescents. All articles are freely available online, via SciELO. Its abbreviated title is Rev. Paul. Pediatr., which should be used in bibliographies, footnotes and bibliographical references and strips.