Age-Related Menopause and Carbonyl Stress

IF 0.6 Q4 GERIATRICS & GERONTOLOGY
A. S. Brichagina, N. V. Semenova, L. I. Kolesnikova
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引用次数: 0

Abstract

The review analyzes the published data of some studies on redox homeostasis in women with age-related physiological menopause. Despite the ambiguity of the presented results on the oxidative modification of lipids, proteins, and carbohydrates, most studies allow us to consider this age period as one of the factors in the development of carbonyl stress, which is an integral part of aging. The presence of hyperglycemia and free-radical pathology are presented as the main causes of the development of carbonyl stress; age-related deficiency of estrogens, taking into account their antioxidant properties, is considered as one of the triggers for the development of this condition, and the glutathione system is defined as one of its main inhibitors.

与年龄相关的更年期和羰基应激
本综述分析了一些已发表的关于年龄相关性生理绝经妇女氧化还原稳态的研究数据。尽管目前关于脂质、蛋白质和碳水化合物氧化修饰的结果尚不明确,但大多数研究都允许我们将这一年龄阶段视为羰基应激发展的因素之一,而羰基应激是衰老的一个组成部分。高血糖和自由基病理的存在是羰基应激发展的主要原因;考虑到其抗氧化特性,与年龄相关的雌激素缺乏被认为是引发这种疾病的诱因之一,而谷胱甘肽系统被定义为其主要抑制剂之一。
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来源期刊
Advances in Gerontology
Advances in Gerontology GERIATRICS & GERONTOLOGY-
CiteScore
0.80
自引率
16.70%
发文量
45
期刊介绍: Advances in Gerontology focuses on biomedical aspects of aging. The journal also publishes original articles and reviews on progress in the following research areas: demography of aging; molecular and physiological mechanisms of aging, clinical gerontology and geriatrics, prevention of premature aging, medicosocial aspects of gerontology, and behavior and psychology of the elderly.
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