Monoamines and Kynurenine Involvement in Pathogenetic Mechanisms of Attention Deficit Hyperactivity Disorder or Hyperkinetic Syndrome

Abstract

The aetiology of ADHD/HKS is not known and pathogenesis is not clear. It has been shown that changes in the central monoaminergic systems play important role in ADHD/HKS [3,4]. Campbell M and Spenser E.K [5] wrote that “It remains to be shown where discrete biochemically based subgroups show a different response to drugs: to psychostimulants, imipramine or neuroleptics” (p. 273). In spite that it was written 30 years ago the problem still remains urgent.