Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity

IF 1.7 Q3 UROLOGY & NEPHROLOGY

International Journal of Nephrology Pub Date : 2022-04-16 DOI:10.1155/2022/5096825

M. A. Ayza, Kaleab Alemayehu Zewdie, Elias Fitsum Yigzaw, Solomon Gashaw Ayele, B. Tesfaye, Gebrehiwot Gebremedihn Tafere, Muzey Gebreyohannes Abrha

引用次数: 10

Abstract

Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types of cancer treatments and as an immunosuppressive agent for the management of autoimmune and immune-mediated diseases. Nowadays, its clinical use is limited due to various toxicities, including nephrotoxicity. Even though the mechanisms are not well understood, cyclophosphamide-induced nephrotoxicity is reported to be mediated through oxidative stress. This review focuses on the potential role of natural and plant-derived antioxidants in preventing cyclophosphamide-induced nephrotoxicity.

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抗氧化剂对环磷酰胺所致肾毒性的潜在保护作用

环磷酰胺是一种烷基化抗肿瘤药物，是最成功的药物之一，具有广泛的临床活性。它已用于多种类型的癌症治疗，并作为免疫抑制剂用于管理自身免疫和免疫介导的疾病。目前，由于各种毒性，包括肾毒性，其临床应用受到限制。尽管其机制尚不清楚，但据报道，环磷酰胺诱导的肾毒性是通过氧化应激介导的。这篇综述的重点是天然和植物来源的抗氧化剂在预防环磷酰胺诱导的肾毒性中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nephrology UROLOGY & NEPHROLOGY-

CiteScore

3.40

自引率

4.80%

发文量

审稿时长

17 weeks

期刊介绍： International Journal of Nephrology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on the prevention, diagnosis, and management of kidney diseases and associated disorders. The journal welcomes submissions related to cell biology, developmental biology, genetics, immunology, pathology, pathophysiology of renal disease and progression, clinical nephrology, dialysis, and transplantation.