Benefits and warnings after one year of Minimed 780 G hybrid closed loop pump treatment in type 1 diabetes adults

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-10-01 DOI:10.1016/j.deman.2022.100110

Didier Gouet , Pierre Henri Ducluzeau , Harivola Andriantaolo , Claire Cordroc'h , Frédérique Duengler , Sophie Gaulier , Thierry Godeau , Céline Olivier , Caroline Allix-Beguec

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引用次数: 0

Abstract

The benefits of a hybrid closed loop insulin pump system are generally compared to non-automated insulin pump treatment of type 1 diabetics whose glycemic control was often unsatisfactory. Here we report the results of a monocentric cohort of type 1 diabetics with a good glycemic control before the switch to the hybrid system. 83 adult patients were followed up for 12 months after the implementation and training of the hybrid system. We observed a significant improvement in the glycemic mean index at 3 and 6 months but not at 12 months, accompanied by a 10% increase in insulin requirements over the first few months. Surprisingly, the time spent in hypoglycemia did not decrease. An analysis shared with patients leads us to propose several measures to consider before switching to a hybrid closed loop system.

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1型糖尿病成人最低780 G混合型闭环泵治疗1年后的益处和警告

对于血糖控制不理想的1型糖尿病患者，通常将混合型闭环胰岛素泵系统的益处与非自动化胰岛素泵治疗进行比较。在此，我们报告了在切换到混合系统之前血糖控制良好的1型糖尿病患者的单中心队列的结果。83例成人患者在混合系统实施和训练后随访12个月。我们观察到在第3个月和第6个月时血糖平均指数有显著改善，但在第12个月时没有，同时在最初几个月胰岛素需求增加了10%。令人惊讶的是，处于低血糖状态的时间并没有减少。与患者分享的分析使我们提出了在切换到混合闭环系统之前要考虑的几个措施。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.