Huibin Tang, Michael Kim, Myung Lee, Kellie Baumann, F. Olguin, Hao He, Yoyo Wang, B. Jiang, Shuhuan Fang, Jinguo Zhu, Kun Wang, Hui Xia, Yang Gao, Harrison B. Konsker, Emmanuel Fatodu, Marco Quarta, Justin Blonigan, T. Rando, J. Shrager
{"title":"Overexpression of thioredoxin‐2 attenuates age‐related muscle loss by suppressing mitochondrial oxidative stress and apoptosis","authors":"Huibin Tang, Michael Kim, Myung Lee, Kellie Baumann, F. Olguin, Hao He, Yoyo Wang, B. Jiang, Shuhuan Fang, Jinguo Zhu, Kun Wang, Hui Xia, Yang Gao, Harrison B. Konsker, Emmanuel Fatodu, Marco Quarta, Justin Blonigan, T. Rando, J. Shrager","doi":"10.1002/rco2.57","DOIUrl":null,"url":null,"abstract":"Skeletal muscle mass is regulated by intracellular anabolic and catabolic activities. Increased catabolic activity can shift the balance towards net protein breakdown and muscle atrophy. Mitochondrial oxidative stress activates catabolism and is linked to muscle loss. Reducing mitochondrial oxidative stress is thus a plausible approach to prevent muscle atrophy. We tested this concept in age‐dependent muscle atrophy by genetically overexpressing the mitochondrial antioxidant thioredoxin‐2 (TXN2).","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"5 1","pages":"130 - 145"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JCSM rapid communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/rco2.57","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
Skeletal muscle mass is regulated by intracellular anabolic and catabolic activities. Increased catabolic activity can shift the balance towards net protein breakdown and muscle atrophy. Mitochondrial oxidative stress activates catabolism and is linked to muscle loss. Reducing mitochondrial oxidative stress is thus a plausible approach to prevent muscle atrophy. We tested this concept in age‐dependent muscle atrophy by genetically overexpressing the mitochondrial antioxidant thioredoxin‐2 (TXN2).
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
