Ludartin exhibits therapeutic effect on spinal cord injury through inhibition of apoptosis and inflammation

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2019-02-28 DOI:10.3329/BJP.V14I1.38725

Weiyuan Xu, S. Miao, Yuchen Feng

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引用次数: 1

Abstract

The present study investigates the effect of ludartin on spinal cord injury in rat model. Ludartin treatment decreased the expression of myeloperoxidase and malondialdehyde in spinal cord tissues. The expression of glutathione and superoxide dismutase was enhanced. It also exhibited inhibitory effect on reduction of NeuN-positive cells. The proportion of TUNEL positive cells was also regulated. In addition, ludartin treatment prevented the onset of apoptosis which was evident by decrease in caspase-3 and Bax level and increase of Bcl‑2 level. Up-regulation of tumor necrosis factor‑α, inter-leukin‑1β and I interleukin‑6 by spinal cord injury was suppressed by ludartin treatment. There was improvement in locomotion of rats by treatment with ludartin. Ludartin treatment of spinal cord injury rats improves locomotion by inhibiting inflammatory cytokine expression and preventing cell apoptosis. Thus, ludartin has therapeutic importance in spinal cord injury treatment. Video Clip of Methodology: 3 min 35 sec: Full Screen Alternate

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芦丁素通过抑制细胞凋亡和炎症对脊髓损伤有治疗作用

本研究探讨芦丁对大鼠脊髓损伤模型的影响。芦丁治疗降低脊髓组织中髓过氧化物酶和丙二醛的表达。谷胱甘肽和超氧化物歧化酶的表达增强。对neun阳性细胞的减少也有抑制作用。TUNEL阳性细胞比例也受到调节。此外，ludtin治疗可阻止细胞凋亡的发生，其表现为caspase-3和Bax水平降低，Bcl - 2水平升高。ludtin可抑制脊髓损伤后肿瘤坏死因子α、白细胞介素1β和白细胞介素6的上调。芦丁对大鼠运动能力有改善作用。ludtin治疗脊髓损伤大鼠通过抑制炎性细胞因子表达和防止细胞凋亡改善运动能力。因此，ludtin在脊髓损伤治疗中具有重要的治疗意义。方法论视频剪辑:3分35秒:全屏交替播放

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.