Effect of Bezafibrate, a PPARα Activator, on Acute and Subacute Inflammation in Male Wistar Rats

IF 0.4 Q4 PHARMACOLOGY & PHARMACY
Serah Johny, S. Torgal
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引用次数: 0

Abstract

Aim To investigate the anti-inflammatory effect of bezafibrate on acute and subacute inflammation in adult male Wistar rats. Methods The study was carried out in adult male Wistar rats and they were allocated into three groups, that is, control, aspirin and bezafibrate, after obtaining clearance from Institutional Animal Ethics Committee. Acute inflammation was studied using carrageenan-induced rat paw oedema, and the volume displacement due to paw oedema using the plethysmograph. Subacute inflammation was studied using foreign body induced granuloma models. Analysis was performed using one-way ANOVA followed by post hoc tests of Dunnett’s. The value p < 0.05 was considered statistically significant. Results Bezafibrate showed a significant anti-inflammatory effect in acute as well as subacute models of inflammation when compared to control in the present study. Conclusions In patients receiving bezafibrate for hyperlipidemia, its anti-inflammatory potential may have an additional benefit in preventing complication of atherosclerosis.
PPARα激活剂贝扎贝特对雄性Wistar大鼠急性和亚急性炎症的影响
目的研究苯扎贝特对成年雄性Wistar大鼠急性和亚急性炎症的抗炎作用。方法采用成年雄性Wistar大鼠,经动物伦理委员会批准,分为对照组、阿司匹林组和苯扎贝特组。使用卡拉胶诱导的大鼠爪水肿研究急性炎症,并使用体积描记器研究爪水肿引起的体积位移。使用异物诱导的肉芽肿模型研究亚急性炎症。使用单因素方差分析进行分析,然后进行Dunnett的事后检验。p<0.05被认为具有统计学意义。结果在本研究中,与对照组相比,贝扎贝特在急性和亚急性炎症模型中显示出显著的抗炎作用。结论在接受苯扎贝特治疗高脂血症的患者中,其抗炎潜力可能对预防动脉粥样硬化并发症有额外的益处。
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来源期刊
CiteScore
0.40
自引率
0.00%
发文量
37
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