Phytochemical analysis, cytotoxic, antioxidant and anti-diabetic activities of the aerial parts of Sorghum halepense

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2019-08-21 DOI:10.3329/BJP.V14I3.40292

Muhammad Abdur Rehman Shah, R. Khan, Mushtaq Ahmed

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引用次数: 9

Abstract

Phytochemical screening, cytotoxic activity, total phenolic content, antioxidant and anti-diabetic activities of the Sorghum halepense methanolic extract and its different fractions were evaluated. Methanolic extract and its various fractions revealed the presence of reducing sugars, tannins, steroids, glycosides, flavonoids in the methanolic extract where they were absent in n-hexane fraction except flavonoids. Gums and saponins were absent in all the samples. Methanolic extract indicated the highest cytotoxic (80.7 ± 1.3%) and anti-diabetic (62.5%) activities. The maximum total phenolic contents (28.7 ± 1.4 mg/mL) were found in the chloroform fraction. An aqueous fraction expressed the highest antioxidant activity 74.1 and 97.1% free radical scavenging properties in DPPH and ABTS assays respectively whereas, in the case of H2O2, methanolic extract indicated maximum (36.9%) activity. In conclusion, the extract of aerial parts of S. halepense is a source of compounds against cancer, diabetic and free radical associated disorders.

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高粱地上部分的植物化学分析、细胞毒、抗氧化和抗糖尿病活性

对高梁甲醇提取物及其不同组分的植物化学筛选、细胞毒性、总酚含量、抗氧化和抗糖尿病活性进行了评价。甲醇提取物及其各种组分显示甲醇提取物中存在还原糖、单宁、类固醇、糖苷和黄酮类化合物，而正己烷组分中除黄酮类化合物外不存在这些物质。所有样品中均不含口香糖和皂苷。甲醇提取物具有最高的细胞毒性（80.7±1.3%）和抗糖尿病（62.5%）活性。氯仿组分中总酚含量最高（28.7±1.4 mg/mL）。在DPPH和ABTS测定中，水性组分分别表现出最高的抗氧化活性74.1%和97.1%的自由基清除特性，而在H2O2的情况下，甲醇提取物表现出最高（36.9%）的活性。总之，海鞘地上部分的提取物是抗癌症、糖尿病和自由基相关疾病的化合物的来源。

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.